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General-Purpose Ultrasound Neuromodulation System for Chronic, Closed-Loop Preclinical Studies in Freely Behaving Rodents

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Title
General-Purpose Ultrasound Neuromodulation System for Chronic, Closed-Loop Preclinical Studies in Freely Behaving Rodents
Author(s)
Jo, Yehhyun; Lee, Sang-Mok; Jung, Taesub; Park, Gijae; Chanhee Lee; Geun Ho Im; Lee, Seongju; Park, Jin Soo; Oh, Chaerin; Kook, Geon; Kim, Hyunggug; Kim, Seongyeon; Lee, Byung Chul; Suh, Greg S. B.; Seong-Gi Kim; Kim, Jeongyeon; Lee, Hyunjoo J.
Publication Date
2022-12
Journal
ADVANCED SCIENCE, v.9, no.34
Publisher
WILEY
Abstract
Transcranial focused ultrasound stimulation (tFUS) is an effective noninvasive treatment modality for brain disorders with high clinical potential. However, the therapeutic effects of ultrasound neuromodulation are not widely explored due to limitations in preclinical systems. The current preclinical studies are head-fixed, anesthesia-dependent, and acute, limiting clinical translatability. Here, this work reports a general-purpose ultrasound neuromodulation system for chronic, closed-loop preclinical studies in freely behaving rodents. This work uses microelectromechanical systems (MEMS) technology to design and fabricate a small and lightweight transducer capable of artifact-free stimulation and simultaneous neural recording. Using the general-purpose system, it can be observed that state-dependent ultrasound neuromodulation of the prefrontal cortex increases rapid eye movement (REM) sleep and protects spatial working memory to REM sleep deprivation. The system will allow explorative studies in brain disease therapeutics and neuromodulation using ultrasound stimulation for widespread clinical adoption.
URI
https://pr.ibs.re.kr/handle/8788114/12518
DOI
10.1002/advs.202202345
ISSN
2198-3844
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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