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Three-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming

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dc.contributor.authorJin, Yoonhee-
dc.contributor.authorKim, Hyeok-
dc.contributor.authorMin, Sungjin-
dc.contributor.authorChoi, Yi Sun-
dc.contributor.authorSeo, Seung Ju-
dc.contributor.authorJeong, Eunseon-
dc.contributor.authorKim, Su Kyeom-
dc.contributor.authorLee, Hyang-Ae-
dc.contributor.authorJo, Sung-Hyun-
dc.contributor.authorPark, Jae-Hyun-
dc.contributor.authorPark, Bong-Woo-
dc.contributor.authorSim, Woo-Sup-
dc.contributor.authorKim, Jin-Ju-
dc.contributor.authorBan, Kiwon-
dc.contributor.authorKim, Yun-Gon-
dc.contributor.authorPark, Hun-Jun-
dc.contributor.authorSeung-Woo Cho-
dc.date.accessioned2023-01-26T02:22:42Z-
dc.date.available2023-01-26T02:22:42Z-
dc.date.created2023-01-02-
dc.date.issued2022-12-
dc.identifier.issn2375-2548-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12482-
dc.description.abstract© 2022 The Authors.Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac regeneration. Full chemical reprogramming with small molecules to generate cardiomyocytes may be more amenable than genetic reprogramming for clinical applications as it avoids safety concerns associated with genetic manipulations. However, challenges remain regarding low conversion efficiency and incomplete cardiomyocyte maturation. Furthermore, the therapeutic potential of chemically induced cardiomyocytes (CiCMs) has not been investigated. Here, we report that a three-dimensional microenvironment reconstituted with decellularized heart extracellular matrix can enhance chemical reprogramming and cardiac maturation of fibroblasts to cardiomyocytes. The resultant CiCMs exhibit elevated cardiac marker expression, sarcomeric organization, and improved electrophysiological features and drug responses. We investigated the therapeutic potential of CiCMs reprogrammed in three-dimensional heart extracellular matrix in a rat model of myocardial infarction. Our platform can facilitate the use of CiCMs for regenerative medicine, disease modeling, and drug screening.-
dc.language영어-
dc.publisherAmerican Association for the Advancement of Science-
dc.titleThree-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000905194200020-
dc.identifier.scopusid2-s2.0-85144232186-
dc.identifier.rimsid79592-
dc.contributor.affiliatedAuthorSeung-Woo Cho-
dc.identifier.doi10.1126/sciadv.abn5768-
dc.identifier.bibliographicCitationScience Advances, v.8, no.50-
dc.relation.isPartOfScience Advances-
dc.citation.titleScience Advances-
dc.citation.volume8-
dc.citation.number50-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusCARDIOMYOCYTE-LIKE CELLS-
dc.subject.keywordPlusEMBRYONIC STEM-CELLS-
dc.subject.keywordPlusMOUSE FIBROBLASTS-
dc.subject.keywordPlusOPTIMIZATION-
dc.subject.keywordPlusELASTICITY-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusMYOCYTES-
dc.subject.keywordPlusYAP/TAZ-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusCUES-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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