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Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

Cited 48 time in webofscience Cited 48 time in scopus
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Title
Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells
Author(s)
Seongchan Kim; Soo-Ryoon Ryoo; Hee-Kyung Na; Young-Kwan Kim; Byong-Seok Choi; Younghoon Lee; Dong-Eun Kim; Dal-Hee Min
Publication Date
2013-09
Journal
CHEMICAL COMMUNICATIONS, v.49, no.74, pp.8241 - 8243
Publisher
ROYAL SOC CHEMISTRY
Abstract
The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.
URI
https://pr.ibs.re.kr/handle/8788114/1247
DOI
10.1039/c3cc43368d
ISSN
1359-7345
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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