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Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells
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- Title
- Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells
- Author(s)
- Seongchan Kim; Soo-Ryoon Ryoo; Hee-Kyung Na; Young-Kwan Kim; Byong-Seok Choi; Younghoon Lee; Dong-Eun Kim; Dal-Hee Min
- Publication Date
- 2013-09
- Journal
- CHEMICAL COMMUNICATIONS, v.49, no.74, pp.8241 - 8243
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.
- ISSN
- 1359-7345
- Appears in Collections:
- Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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