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나노물질및화학반응연구단
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Poly(ethylene glycol)- and carboxylate-functionalized gold nanoparticles using polymer linkages: Single-step synthesis, high stability, and plasmonic detection of proteins

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dc.contributor.authorGaram Park-
dc.contributor.authorDaeha Seo-
dc.contributor.authorChung I.S.-
dc.contributor.authorHyunjoon Song-
dc.date.available2015-04-20T06:38:04Z-
dc.date.created2014-09-12-
dc.date.issued2013-10-
dc.identifier.issn0743-7463-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1228-
dc.description.abstractGold nanoparticles with suitable surface functionalities have been widely used as a versatile nanobioplatform. However, functionalized gold nanoparticles using thiol-terminated ligands have a tendency to aggregate, particularly in many enzymatic reaction buffers containing biological thiols, because of ligand exchange reactions. In the present study, we developed a one-step synthesis of poly(ethylene glycol) (PEG)ylated gold nanoparticles using poly(dimethylaminoethyl methacrylate) (PDMAEMA) in PEG as a polyol solvent. Because of the chelate effect of polymeric functionalities on the gold surface, the resulting PEGylated gold nanoparticles (Au@P-PEG) are very stable under the extreme conditions at which the thiol-monolayer-protected gold nanoparticles are easily coagulated. Using the solvent mixture of PEG and ethylene glycol (EG) and subsequent hydrolysis, gold nanoparticles bearing mixed functionalities of PEG and carboxylate are generated. The resulting particles exhibit selective adsorption of positively charged chymotrypsin (ChT) without nonselective adsorption of bovine serum albumin (BSA). The present nanoparticle system has many advantages, including high stability, simple one-step synthesis, biocompatibility, and excellent binding specificity; thus, this system can be used as a versatile platform for potential bio-related applications, such as separation, sensing, imaging, and assays.-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.subjectBinding specificities-
dc.subjectBovine serum albumins-
dc.subjectDimethylaminoethyl methacrylates-
dc.subjectFunctionalized gold nanoparticles-
dc.subjectLigand exchange reactions-
dc.subjectSingle-step synthesis-
dc.subjectSubsequent hydrolysis-
dc.subjectSurface functionalities-
dc.subjectAdsorption-
dc.subjectBiocompatibility-
dc.subjectBiosynthesis-
dc.subjectCarboxylation-
dc.subjectEthylene glycol-
dc.subjectMetal nanoparticles-
dc.subjectOrganic solvents-
dc.subjectPolyethylene glycols-
dc.subjectPolymers-
dc.subjectGold-
dc.subjectbovine serum albumin-
dc.subjectcarboxylic acid-
dc.subjectchymotrypsin-
dc.subjectgold-
dc.subjectmacrogol derivative-
dc.subjectmetal nanoparticle-
dc.subjectmethacrylic acid derivative-
dc.subjectnylon-
dc.subjectpoly(2 (diethylamino)ethyl methacrylate)-
dc.subjectpoly(2-(diethylamino)ethyl methacrylate)-
dc.subjectanimal-
dc.subjectarticle-
dc.subjectcattle-
dc.subjectchemistry-
dc.subjectsurface property-
dc.subjectsynthesis-
dc.subjectAnimals-
dc.subjectCarboxylic Acids-
dc.subjectCattle-
dc.subjectChemistry Techniques, Synthetic-
dc.subjectChymotrypsin-
dc.subjectGold-
dc.subjectMetal Nanoparticles-
dc.subjectMethacrylates-
dc.subjectNylons-
dc.subjectPolyethylene Glycols-
dc.subjectSerum Albumin, Bovine-
dc.subjectSurface Properties-
dc.titlePoly(ethylene glycol)- and carboxylate-functionalized gold nanoparticles using polymer linkages: Single-step synthesis, high stability, and plasmonic detection of proteins-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000326711200025-
dc.identifier.scopusid2-s2.0-84887573770-
dc.identifier.rimsid53907ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorGaram Park-
dc.contributor.affiliatedAuthorDaeha Seo-
dc.contributor.affiliatedAuthorHyunjoon Song-
dc.identifier.doi10.1021/la402315a-
dc.identifier.bibliographicCitationLANGMUIR, v.29, no.44, pp.13518 - 13526-
dc.citation.titleLANGMUIR-
dc.citation.volume29-
dc.citation.number44-
dc.citation.startPage13518-
dc.citation.endPage13526-
dc.date.scptcdate2018-10-01-
dc.description.wostc12-
dc.description.scptc15-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Nanomaterials and Chemical Reactions(나노물질 및 화학반응 연구단) > 1. Journal Papers (저널논문)
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