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분자분광학및동력학연구단
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Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues

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dc.contributor.authorWonjun Choi-
dc.contributor.authorMunkyu Kang-
dc.contributor.authorJin Hee Hong-
dc.contributor.authorOri Katz-
dc.contributor.authorByunghak Lee-
dc.contributor.authorGuang Hoon Kim-
dc.contributor.authorYoungwoon Choi-
dc.contributor.authorWonshik Choi-
dc.date.accessioned2022-09-06T22:00:24Z-
dc.date.available2022-09-06T22:00:24Z-
dc.date.created2022-08-26-
dc.date.issued2022-08-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12272-
dc.description.abstractLensless fibre endoscopes are minimally invasive, but are often rigid and require calibration and fluorescence labelling. Here, the authors present a flexible endoscope based on a bare fibre bundle and a lensless Fourier holographic imaging configuration to detect weak reflections from unstained biological tissues. Ultrathin lensless fibre endoscopes offer minimally invasive investigation, but they mostly operate as a rigid type due to the need for prior calibration of a fibre probe. Furthermore, most implementations work in fluorescence mode rather than label-free imaging mode, making them unsuitable for general medical diagnosis. Herein, we report a fully flexible ultrathin fibre endoscope taking 3D holographic images of unstained tissues with 0.85-mu m spatial resolution. Using a bare fibre bundle as thin as 200-mu m diameter, we design a lensless Fourier holographic imaging configuration to selectively detect weak reflections from biological tissues, a critical step for label-free endoscopic reflectance imaging. A unique algorithm is developed for calibration-free holographic image reconstruction, allowing us to image through a narrow and curved passage regardless of fibre bending. We demonstrate endoscopic reflectance imaging of unstained rat intestine tissues that are completely invisible to conventional endoscopes. The proposed endoscope will expedite a more accurate and earlier diagnosis than before with minimal complications.-
dc.language영어-
dc.publisherNATURE PORTFOLIO-
dc.titleFlexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000836703600013-
dc.identifier.scopusid2-s2.0-85135267529-
dc.identifier.rimsid78738-
dc.contributor.affiliatedAuthorWonjun Choi-
dc.contributor.affiliatedAuthorMunkyu Kang-
dc.contributor.affiliatedAuthorJin Hee Hong-
dc.contributor.affiliatedAuthorWonshik Choi-
dc.identifier.doi10.1038/s41467-022-32114-5-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.13, no.1-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume13-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlus2-PHOTON MICROSCOPE-
dc.subject.keywordPlusFIBER BUNDLE-
dc.subject.keywordPlusENDOMICROSCOPY-
dc.subject.keywordPlusCOMPENSATION-
dc.subject.keywordPlusDEEP-
dc.subject.keywordAuthor2-PHOTON MICROSCOPEFIBER BUNDLEENDOMICROSCOPYCOMPENSATIONDEEP-
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > 1. Journal Papers (저널논문)
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