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Iridium-catalyzed direct arene C-H bond amidation with sulfonyl- and aryl azides

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Title: Iridium-catalyzed direct arene C-H bond amidation with sulfonyl- and aryl azides

Subject: Amidation, ; Aryl azides, ; C-H bond, ; Directing groups, ; High selectivity, ; Nitrogen sources, ; Functional groups, ; Iridium, ; Nitrogen compounds, ; Catalysis, ; azide, ; iridium, ; nitrogen, ; polycyclic aromatic hydrocarbon derivative, ; amidation, ; article, ; chemical reaction, ; covalent bond

Abstract: Iridium-catalyzed direct ortho C-H amidation of arenes has been shown to work well with sulfonyl- and aryl azides as the nitrogen source. The reaction proceeds efficiently with a broad range of substrates bearing conventional directing groups with excellent functional group compatibility under mild conditions. In addition, substrates forming not only 5- but also 6-membered iridacycle intermediates undergo the C-H amidation with high selectivity. © 2013 American Chemical Society.