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A Miniaturized 256-Channel Neural Recording Interface With Area-Efficient Hybrid Integration of Flexible Probes and CMOS Integrated Circuits

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dc.contributor.authorSung-Yun Park-
dc.contributor.authorKyounghwan Na-
dc.contributor.authorMihaly Voroslakos-
dc.contributor.authorHyunsoo Song-
dc.contributor.authorNathan Slager-
dc.contributor.authorSungjin Oh-
dc.contributor.authorJohn P. Seymour-
dc.contributor.authorGyorgy Buzsaki-
dc.contributor.authorEuisik Yoon-
dc.date.accessioned2022-07-29T07:55:31Z-
dc.date.available2022-07-29T07:55:31Z-
dc.date.created2022-01-03-
dc.date.issued2022-01-
dc.identifier.issn0018-9294-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12069-
dc.description.abstractWe report a miniaturized, minimally invasive high-density neural recording interface that occupies only a 1.53 mm(2) footprint for hybrid integration of a flexible probe and a 256-channel integrated circuit chip. To achieve such a compact form factor, we developed a custom flip-chip bonding technique using anisotropic conductive film and analog circuit-under-pad in a tiny pitch of 75 mu m. To enhance signal-to-noise ratios, we applied a reference-replica topology that can provide the matched input impedance for signal and reference paths in low-noise aimpliers (LNAs). The analog front-end (AFE) consists of LNAs, buffers, programmable gain amplifiers, 10b ADCs, a reference generator, a digital controller, and serial-peripheral interfaces (SPIs). The AFE consumes 51.92 mu W from 1.2 V and 1.8 V supplies in an area of 0.0161 mm(2) per channel, implemented in a 180 nm CMOS process. The AFE shows > 60 dB mid-band CMRR, 6.32 mu V-rms input-referred noise from 0.5 Hz to 10 kHz, and 48 M omega input impedance at 1 kHz. The fabricated AFE chip was directly flip-chip bonded with a 256-channel flexible polyimide neural probe and assembled in a tiny head-stage PCB. Full functionalities of the fabricated 256-channel interface were validated in both in vitro and in vivo experiments, demonstrating the presented hybrid neural recording interface is suitable for various neuroscience studies in the quest of large scale, miniaturized recording systems.-
dc.language영어-
dc.publisherInstitute of Electrical and Electronics Engineers-
dc.titleA Miniaturized 256-Channel Neural Recording Interface With Area-Efficient Hybrid Integration of Flexible Probes and CMOS Integrated Circuits-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000733943200038-
dc.identifier.scopusid2-s2.0-85112170700-
dc.identifier.rimsid77002-
dc.contributor.affiliatedAuthorEuisik Yoon-
dc.identifier.doi10.1109/TBME.2021.3093542-
dc.identifier.bibliographicCitationIEEE Transactions on Biomedical Engineering, v.69, no.1, pp.334 - 346-
dc.relation.isPartOfIEEE Transactions on Biomedical Engineering-
dc.citation.titleIEEE Transactions on Biomedical Engineering-
dc.citation.volume69-
dc.citation.number1-
dc.citation.startPage334-
dc.citation.endPage346-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.subject.keywordPlusMICROELECTRODE ARRAY-
dc.subject.keywordPlusFRONT-END-
dc.subject.keywordPlusELECTRODES-
dc.subject.keywordPlusCOMPACT-
dc.subject.keywordAuthorBonding-
dc.subject.keywordAuthorIntegrated circuit interconnections-
dc.subject.keywordAuthorFlip-chip devices-
dc.subject.keywordAuthorPolyimides-
dc.subject.keywordAuthorCMOS integrated circuits-
dc.subject.keywordAuthorMicroelectrodes-
dc.subject.keywordAuthorAnalog circuit-under-pad-
dc.subject.keywordAuthorneural interface-
dc.subject.keywordAuthorhybrid integration-
dc.subject.keywordAuthoranisotropic conductive film-
dc.subject.keywordAuthorCMOS integrated circuit-
dc.subject.keywordAuthorelectrophysiology-
dc.subject.keywordAuthorminimally invasive-
dc.subject.keywordAuthorreference-replica technique-
dc.subject.keywordAuthorimpedance buffering-
dc.subject.keywordAuthorProbes-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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