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Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics

Cited 115 time in webofscience Cited 0 time in scopus
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Title
Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics
Author(s)
McCall, Jordan G.; Tae-il Kim; Shin, Gunchul; Huang, Xian; Jung, Yei Hwan; Al-Hasani, Ream; Omenetto, Fiorenzo G.; Bruchas, Michael R.; Rogers, John A.
Subject
scavenger, ; animal experiment, ; article, ; brain electrophysiology, ; connectome, ; controlled study, ; electronic sensor, ; feasibility study, ; in vivo study, ; light emitting diode, ; male, ; microtechnology, ; mouse, ; nerve cell network, ; nonhuman, ; optogenetics, ; priority journal, ; product development, ; radiofrequency
Publication Date
2013-12
Journal
NATURE PROTOCOLS, v.8, no.12, pp.2413 - 2428
Publisher
NATURE PUBLISHING GROUP
Abstract
The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering, as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely on rigid fiber optics tethered to external light sources, these novel devices carry wirelessly powered microscale, inorganic light-emitting diodes (μ-ILEDs) and multimodal sensors inside the brain. We describe the technical procedures for construction of these devices, their corresponding radiofrequency power scavengers and their implementation in vivo for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin in vivo experimentation, can be completed in ~3-8 weeks. Implementation of these devices allows for chronic (tested for up to 6 months) wireless optogenetic manipulation of neural circuitry in animals navigating complex natural or home-cage environments, interacting socially, and experiencing other freely moving behaviors. © 2013 Nature America, Inc.
URI
https://pr.ibs.re.kr/handle/8788114/1204
DOI
10.1038/nprot.2013.158
ISSN
1754-2189
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
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