BROWSE

Related Scientist

CNIR's photo.

CNIR
뇌과학 이미징 연구단
more info

ITEM VIEW & DOWNLOAD

Plant-inspired Pluronic-gallol micelles with low critical micelle concentration, high colloidal stability, and protein affinity

Cited 0 time in webofscience Cited 0 time in scopus
34 Viewed 0 Downloaded
Title
Plant-inspired Pluronic-gallol micelles with low critical micelle concentration, high colloidal stability, and protein affinity
Author(s)
Kim, Jungwoo; Ju, Jaewon; Kim, Sung Dong; Mikyung Shin
Publication Date
2022-07
Journal
BIOMATERIALS SCIENCE, v.10, no.14, pp.65 - 78
Publisher
ROYAL SOC CHEMISTRY
Abstract
Polymeric micelles are the most common carriers used for hydrophobic drug delivery. However, they are vulnerable to physiological barriers, such as temperature changes and enzymatic degradation, and can be easily disassembled upon dilution below the critical micelle concentration (CMC) by body fluids after an intravenous injection. Here, we report that Pluronic (R) micelles with octyl gallate, which is a surfactant containing gallol moieties widely found in antioxidative plant polyphenols, have a low CMC, which improves their colloidal stability without the need for covalent crosslinking. Furthermore, the incorporated gallol moieties provide enzymatic degradation resistance to the micelles owing to their protein affinity, maintaining the hydrophobic cavity of unmodified Pluronic (R). Thus, plant-inspired polymeric micelles with low CMC and bioavailability are promising multifunctional vehicles for drug delivery.
URI
https://pr.ibs.re.kr/handle/8788114/12010
DOI
10.1039/d2bm00630h
ISSN
2047-4830
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse