BROWSE

Related Scientist

RNA's photo.

RNA
RNA 연구단
more info

ITEM VIEW & DOWNLOAD

Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia

Cited 0 time in webofscience Cited 0 time in scopus
23 Viewed 0 Downloaded
Title
Hepatic GSK3β-Dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia
Author(s)
Kim, Ye Young; Jang, Hagoon; Lee, Gung; Jeon, Yong Geun; Sohn, Jee Hyung; Han, Ji Seul; Lee, Won Taek; Park, Jeu; Huh, Jin Young; Nahmgoong, Hahn; Han, Sang Mun; Jeesoo Kim; Pak, Minwoo; Kim, Sun; Jong-Seo Kim; Kim, Jae Bum
Publication Date
2022-07
Journal
Diabetes, v.71, no.7, pp.1373 - 1387
Publisher
NLM (Medline)
Abstract
© 2022 by the American Diabetes Association.Excessive hepatic glucose production (HGP) is a key factor promoting hyperglycemia in diabetes. Hepatic cryptochrome 1 (CRY1) plays an important role in maintaining glucose homeostasis by suppressing forkhead box O1 (FOXO1)-mediated HGP. Although downregulation of hepatic CRY1 appears to be associated with increased HGP, the mechanism(s) by which hepatic CRY1 dysregulation confers hyperglycemia in subjects with diabetes is largely unknown. In this study, we demonstrate that a reduction in hepatic CRY1 protein is stimulated by elevated E3 ligase F-box and leucine-rich repeat protein 3 (FBXL3)-dependent proteasomal degradation in diabetic mice. In addition, we found that GSK3β-induced CRY1 phosphorylation potentiates FBXL3-dependent CRY1 degradation in the liver. Accordingly, in diabetic mice, GSK3β inhibitors effectively decreased HGP by facilitating the effect of CRY1-mediated FOXO1 degradation on glucose metabolism. Collectively, these data suggest that tight regulation of hepatic CRY1 protein stability is crucial for maintaining systemic glucose homeostasis.
URI
https://pr.ibs.re.kr/handle/8788114/12009
DOI
10.2337/db21-0649
ISSN
0012-1797
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse