BROWSE

Related Scientist

CNIR's photo.

CNIR
뇌과학 이미징 연구단
more info

ITEM VIEW & DOWNLOAD

Adolescent development of multiscale structural wiring and functional interactions in the human connectome

Cited 0 time in webofscience Cited 0 time in scopus
34 Viewed 0 Downloaded
Title
Adolescent development of multiscale structural wiring and functional interactions in the human connectome
Author(s)
Bo-Yong Park; Paquola, Casey; Bethlehem, Richard A.I.; Benkarim, Oualid; Mišić, Bratislav; Smallwood, Jonathan; Bullmore, Edward T.; Bernhardt, Boris C.
Publication Date
2022-07
Journal
Proceedings of the National Academy of Sciences of the United States of America, v.119, no.27
Publisher
National Academy of Sciences
Abstract
Copyright © 2022 the Author(s).Adolescence is a time of profound changes in the physical wiring and function of the brain. Here, we analyzed structural and functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y (n = 199). Core to our work was an advanced in vivo model of cortical wiring incorporating MRI features of corticocortical proximity, microstructural similarity, and white matter tractography. Longitudinal analyses assessing age-related changes in cortical wiring identified a continued differentiation of multiple corticocortical structural networks in youth. We then assessed structure–function coupling using resting-state functional MRI measures in the same participants both via cross-sectional analysis at baseline and by studying longitudinal change between baseline and follow-up scans. At baseline, regions with more similar structural wiring were more likely to be functionally coupled. Moreover, correlating longitudinal structural wiring changes with longitudinal functional connectivity reconfigurations, we found that increased structural differentiation, particularly between sensory/unimodal and default mode networks, was reflected by reduced functional interactions. These findings provide insights into adolescent development of human brain structure and function, illustrating how structural wiring interacts with the maturation of macroscale functional hierarchies.
URI
https://pr.ibs.re.kr/handle/8788114/12001
DOI
10.1073/pnas.2116673119
ISSN
0027-8424
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse