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혈관 연구단
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Increased capillary stalling is associated with endothelial glycocalyx loss in subcortical vascular dementia

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Title
Increased capillary stalling is associated with endothelial glycocalyx loss in subcortical vascular dementia
Author(s)
Jin-Hui Yoon; Shin, Paul; Joo, Jongyoon; Kim, Gaon S; Oh, Wang-Yuhl; Jeong, Yong
Publication Date
2022-08
Journal
Journal of Cerebral Blood Flow and Metabolism, v.42, no.8, pp.1383 - 1397
Publisher
SAGE Publications Ltd
Abstract
© The Author(s) 2022.Proper regulation and patency of cerebral microcirculation are crucial for maintaining a healthy brain. Capillary stalling, i.e., the brief interruption of microcirculation has been observed in the normal brain and several diseases related to microcirculation. We hypothesized that endothelial glycocalyx, which is located on the luminal side of the vascular endothelium and involved in cell-to-cell interaction regulation in peripheral organs, is also related to cerebral capillary stalling. We measured capillary stalling and the cerebral endothelial glycocalyx (cEG) in male mice using in vivo optical coherence tomography angiography (OCT-A) and two-photon microscopy. Our findings revealed that some capillary segments were prone to capillary stalling and had less cEG. In addition, we demonstrated that the enzymatic degradation of the cEG increased the capillary stalling, mainly by leukocyte plugging. Further, we noted decreased cEG along with increased capillary stalling in a mouse model of subcortical vascular dementia (SVaD) with impaired cortical microcirculation. Moreover, gene expression related to cEG production or degradation changed in the SVaD model. These results indicate that cEG mediates capillary stalling and impacts cerebral blood flow and is involved in the pathogenesis of SVaD.
URI
https://pr.ibs.re.kr/handle/8788114/11972
DOI
10.1177/0271678X221076568
ISSN
0271-678X
Appears in Collections:
Center for Vascular Research(혈관 연구단) > 1. Journal Papers (저널논문)
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