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Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

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Title
Advances in Nanoparticles for Effective Delivery of RNA Therapeutics
Author(s)
Byun, Min Ji; Lim, Jaesung; Kim, Se-Na; Park, Dae-Hwan; Kim, Tae-Hyung; Park, Wooram; Chun Gwon Park
Publication Date
2022-06
Journal
Biochip Journal, v.16, no.2, pp.128 - 145
Publisher
SpringerOpen
Abstract
© 2022, The Korean BioChip Society.RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptide-derived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.
URI
https://pr.ibs.re.kr/handle/8788114/11929
DOI
10.1007/s13206-022-00052-5
ISSN
1976-0280
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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