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Common and stimulus-type-specific brain representations of negative affect

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Title
Common and stimulus-type-specific brain representations of negative affect
Author(s)
Čeko, Marta; Kragel, Philip A.; Choong-Wan Woo; López-Solà, Marina; Wager, Tor D.
Publication Date
2022-06
Journal
Nature Neuroscience, v.25, no.6, pp.760 - 770
Publisher
Nature Research
Abstract
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.The brain contains both generalized and stimulus-type-specific representations of aversive events, but models of how these are integrated and related to subjective experience are lacking. We combined functional magnetic resonance imaging with predictive modeling to identify representations of generalized (common) and stimulus-type-specific negative affect across mechanical pain, thermal pain, aversive sounds and aversive images of four intensity levels each. This allowed us to examine how generalized and stimulus-specific representations jointly contribute to aversive experience. Stimulus-type-specific negative affect was largely encoded in early sensory pathways, whereas generalized negative affect was encoded in a distributed set of midline, forebrain, insular and somatosensory regions. All models specifically predicted negative affect rather than general salience or arousal and accurately predicted negative affect in independent samples, demonstrating robustness and generalizability. Common and stimulus-type-specific models were jointly important for predicting subjective experience. Together, these findings offer an integrated account of how negative affect is constructed in the brain and provide predictive neuromarkers for future studies.
URI
https://pr.ibs.re.kr/handle/8788114/11917
DOI
10.1038/s41593-022-01082-w
ISSN
1097-6256
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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