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A neuroimaging biomarker for sustained experimental and clinical painHighly Cited Paper

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Title
A neuroimaging biomarker for sustained experimental and clinical pain
Author(s)
Jae-Joong Lee; Hong Ji Kim; Marta Čeko; Bo-yong Park; Soo Ahn Lee; Hyunjin Park; Mathieu Roy; Seong-Gi Kim; Tor D. Wager; Choong-Wan Woo
Publication Date
2021-01
Journal
Nature Medicine, v.27, no.1, pp.174 - 182
Publisher
Nature Publishing Group
Abstract
Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in isolation from co-occurring cognitive and emotional features in patients. In this study, we developed a functional magnetic resonance imaging signature based on whole-brain functional connectivity that tracks experimentally induced tonic pain intensity and tested its sensitivity, specificity and generalizability to clinical pain across six studies (total n = 334). The signature displayed high sensitivity and specificity to tonic pain across three independent studies of orofacial tonic pain and aversive taste. It also predicted clinical pain severity and classified patients versus controls in two independent studies of clinical low back pain. Tonic and clinical pain showed similar network-level representations, particularly in somatomotor, frontoparietal and dorsal attention networks. These patterns were distinct from representations of experimental phasic pain. This study identified a brain biomarker for sustained pain with high potential for clinical translation.
URI
https://pr.ibs.re.kr/handle/8788114/11764
DOI
10.1038/s41591-020-1142-7
ISSN
1078-8956
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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