BROWSE

Related Scientist

CNIR's photo.

CNIR
뇌과학 이미징 연구단
more info

ITEM VIEW & DOWNLOAD

Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy

Cited 0 time in webofscience Cited 0 time in scopus
127 Viewed 0 Downloaded
Title
Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy
Author(s)
Bo-yong Park; Lariviere, Sara; Rodriguez-Cruces, Raul; Royer, Jessica; Tavakol, Shahin; Wang, Yezhou; Caciagli, Lorenzo; Caligiuri, Maria Eugenia; Gambardella, Antonio; Concha, Luis; Keller, Simon S.; Cendes, Fernando; Alvim, Marina K. M.; Yasuda, Clarissa; Bonilha, Leonardo; Gleichgerrcht, Ezequiel; Focke, Niels K.; Kreilkamp, Barbara A. K.; Domin, Martin; von Podewils, Felix; Langner, Soenke; Rummel, Christian; Rebsamen, Michael; Wiest, Roland; Martin, Pascal; Kotikalapudi, Raviteja; Bender, Benjamin; O'Brien, Terence J.; Law, Meng; Sinclair, Benjamin; Vivash, Lucy; Kwan, Patrick; Desmond, Patricia M.; Malpas, Charles B.; Lui, Elaine; Alhusaini, Saud; Doherty, Colin P.; Cavalleri, Gianpiero L.; Delanty, Norman; Kalviainen, Reetta; Jackson, Graeme D.; Kowalczyk, Magdalena; Mascalchi, Mario; Semmelroch, Mira; Thomas, Rhys H.; Soltanian-Zadeh, Hamid; Davoodi-Bojd, Esmaeil; Zhang, Junsong; Lenge, Matteo; Guerrini, Renzo; Bartolini, Emanuele; Hamandi, Khalid; Foley, Sonya; Weber, Bernd; Depondt, Chantal; Absil, Julie; Carr, Sarah J. A.; Abela, Eugenio; Richardson, Mark P.; Devinsky, Orrin; Severino, Mariasavina; Striano, Pasquale; Parodi, Costanza; Tortora, Domenico; Hatton, Sean N.; Vos, Sjoerd B.; Duncan, John S.; Galovic, Marian; Whelan, Christopher D.; Bargallo, Nuria; Pariente, Jose; Conde-Blanco, Estefania; Vaudano, Anna Elisabetta; Tondelli, Manuela; Meletti, Stefano; Kong, Xiang-Zhen; Francks, Clyde; Fisher, Simon E.; Caldairou, Benoit; Ryten, Mina; Labate, Angelo; Sisodiya, Sanjay M.; Thompson, Paul M.; McDonald, Carrie R.; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris C.
Publication Date
2022-03
Journal
BRAIN, v.145, no.4, pp.1285 - 1298
Publisher
OXFORD UNIV PRESS
Abstract
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy.
URI
https://pr.ibs.re.kr/handle/8788114/11734
DOI
10.1093/brain/awab417
ISSN
0006-8950
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse