BROWSE

Related Scientist

Researcher

RNA 연구단
RNA 연구단
more info

Facile synthesis and intraparticle self-catalytic oxidation of dextran-coated hollow Au-Ag nanoshell and its application for chemo-thermotherapy

Cited 45 time in webofscience Cited 0 time in scopus
385 Viewed 40 Downloaded
Title
Facile synthesis and intraparticle self-catalytic oxidation of dextran-coated hollow Au-Ag nanoshell and its application for chemo-thermotherapy
Author(s)
Hongje Jang; Young-Kwan Kim; Hyun Huh; Dal-Hee Min
Publication Date
2014-01
Journal
ACS NANO, v.8, no.1, pp.467 - 475
Publisher
AMER CHEMICAL SOC
Abstract
Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow AuAg nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core AuAg nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation via Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Doxloaded AuAg nanoshell as a combinational chemo-thermotherapy to treat cancer cells.
URI
https://pr.ibs.re.kr/handle/8788114/1155
ISSN
1936-0851
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
RNA 21_ACS Nano.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse