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Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoidsHighly Cited Paper

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dc.contributor.authorSuran Kim-
dc.contributor.authorSungjin Min-
dc.contributor.authorYi Sun Choi-
dc.contributor.authorSung-Hyun Jo-
dc.contributor.authorJae Hun Jung-
dc.contributor.authorKyusun Han-
dc.contributor.authorJin Kim-
dc.contributor.authorSoohwan An-
dc.contributor.authorYong Woo Ji-
dc.contributor.authorYun-Gon Kim-
dc.contributor.authorSeung-Woo Cho-
dc.date.accessioned2022-05-25T04:34:52Z-
dc.date.accessioned2022-05-25T04:34:52Z-
dc.date.available2022-05-25T04:34:52Z-
dc.date.available2022-05-25T04:34:52Z-
dc.date.created2022-04-18-
dc.date.issued2022-03-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11455-
dc.description.abstract© 2022, The Author(s).Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to-batch variation, high cost, and safety issues. Here, we demonstrate that gastrointestinal tissue-derived extracellular matrix hydrogels are suitable substitutes for Matrigel in gastrointestinal organoid culture. We found that the development and function of gastric or intestinal organoids grown in tissue extracellular matrix hydrogels are comparable or often superior to those in Matrigel. In addition, gastrointestinal extracellular matrix hydrogels enabled long-term subculture and transplantation of organoids by providing gastrointestinal tissue-mimetic microenvironments. Tissue-specific and age-related extracellular matrix profiles that affect organoid development were also elucidated through proteomic analysis. Together, our results suggest that extracellular matrix hydrogels derived from decellularized gastrointestinal tissues are effective alternatives to the current gold standard, Matrigel, and produce organoids suitable for gastrointestinal disease modeling, drug development, and tissue regeneration.-
dc.language영어-
dc.publisherNature Research-
dc.titleTissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000776282500007-
dc.identifier.scopusid2-s2.0-85127273094-
dc.identifier.rimsid78075-
dc.contributor.affiliatedAuthorSeung-Woo Cho-
dc.identifier.doi10.1038/s41467-022-29279-4-
dc.identifier.bibliographicCitationNature Communications, v.13, no.1-
dc.relation.isPartOfNature Communications-
dc.citation.titleNature Communications-
dc.citation.volume13-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusHUMAN SMALL-INTESTINE-
dc.subject.keywordPlusIN-VITRO EXPANSION-
dc.subject.keywordPlusSTEM-CELL-
dc.subject.keywordPlusHEPARAN-SULFATE-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusDECORIN-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusLAMININ-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusCOLON-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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