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Seung Won, Han
나노물질 및 화학반응 연구단
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Targeting Gut Bacteria Using Inulin-Conjugated Mesoporous Silica Nanoparticles

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Title
Targeting Gut Bacteria Using Inulin-Conjugated Mesoporous Silica Nanoparticles
Author(s)
von Baeckmann, Cornelia; Riva, Alessandra; Guggenberger, Patrick; Kählig, Hanspeter; Seung Won Han; Inan, Deniz; Del Favero, Giorgia; Berry, David; Kleitz, Freddy
Publication Date
2022-05
Journal
Advanced Materials Interfaces, v.9, no.14
Publisher
John Wiley and Sons Inc
Abstract
© 2022 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.To facilitate the creation of novel nanocarrier systems targeting the intestinal microbiome, inulin-conjugated mesoporous silica nanoparticles (MSNs) are described herein for the first time. Surface functionalization is achieved on either hydrophilic or hydrophobic mesoporous nanoparticles using different conjugation methods. The targeting performance of the resulting materials is assessed and compared upon incubation with human stool. It appears that amide formation is the most favorable coupling method on hydrophilic MSNs to achieve the desired bioconjugate. Remarkably, high affinity of gut bacteria to the conjugated particles can be obtained, paving the way to novel targeted drug delivery systems.
URI
https://pr.ibs.re.kr/handle/8788114/11410
DOI
10.1002/admi.202102558
ISSN
2196-7350
Appears in Collections:
Center for Nanomaterials and Chemical Reactions(나노물질 및 화학반응 연구단) > 1. Journal Papers (저널논문)
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