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Disrupted stepwise functional brain organization in overweight individuals

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Title
Disrupted stepwise functional brain organization in overweight individuals
Author(s)
Hyebin Lee; Junmo Kwon; Jong-eun Lee; Bo-yong Park; Hyunjin Park
Publication Date
2022-01
Journal
Communications Biology, v.5, no.1
Publisher
Nature Research
Abstract
© 2022, The Author(s).Functional hierarchy establishes core axes of the brain, and overweight individuals show alterations in the networks anchored on these axes, particularly in those involved in sensory and cognitive control systems. However, quantitative assessments of hierarchical brain organization in overweight individuals are lacking. Capitalizing stepwise functional connectivity analysis, we assess altered functional connectivity in overweight individuals relative to healthy weight controls along the brain hierarchy. Seeding from the brain regions associated with obesity phenotypes, we conduct stepwise connectivity analysis at different step distances and compare functional degrees between the groups. We find strong functional connectivity in the somatomotor and prefrontal cortices in both groups, and both converge to transmodal systems, including frontoparietal and default-mode networks, as the number of steps increased. Conversely, compared with the healthy weight group, overweight individuals show a marked decrease in functional degree in somatosensory and attention networks across the steps, whereas visual and limbic networks show an increasing trend. Associating functional degree with eating behaviors, we observe negative associations between functional degrees in sensory networks and hunger and disinhibition-related behaviors. Our findings suggest that overweight individuals show disrupted functional network organization along the hierarchical axis of the brain and these results provide insights for behavioral associations.
URI
https://pr.ibs.re.kr/handle/8788114/11202
DOI
10.1038/s42003-021-02957-7
ISSN
2399-3642
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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