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Effect sizes and test-retest reliability of the fMRI-based neurologic pain signature

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Title
Effect sizes and test-retest reliability of the fMRI-based neurologic pain signature
Author(s)
Han, Xiaochun; Ashar, Yoni K.; Kragel, Philip; Petre, Bogdan; Schelkun, Victoria; Atlas, Lauren Y.; Chang, Luke J.; Jepma, Marieke; Koban, Leonie; Losin, Elizabeth A. Reynolds; Roy, Mathieu; Choong-Wan Woo; Wager, Tor D.
Publication Date
2022-02
Journal
NeuroImage, v.247
Publisher
Academic Press Inc.
Abstract
© 2021Identifying biomarkers that predict mental states with large effect sizes and high test-retest reliability is a growing priority for fMRI research. We examined a well-established multivariate brain measure that tracks pain induced by nociceptive input, the Neurologic Pain Signature (NPS). In N = 295 participants across eight studies, NPS responses showed a very large effect size in predicting within-person single-trial pain reports (d = 1.45) and medium effect size in predicting individual differences in pain reports (d = 0.49). The NPS showed excellent short-term (within-day) test-retest reliability (ICC = 0.84, with average 69.5 trials/person). Reliability scaled with the number of trials within-person, with ≥60 trials required for excellent test-retest reliability. Reliability was tested in two additional studies across 5-day (N = 29, ICC = 0.74, 30 trials/person) and 1-month (N = 40, ICC = 0.46, 5 trials/person) test-retest intervals. The combination of strong within-person correlations and only modest between-person correlations between the NPS and pain reports indicate that the two measures have different sources of between-person variance. The NPS is not a surrogate for individual differences in pain reports but can serve as a reliable measure of pain-related physiology and mechanistic target for interventions.
URI
https://pr.ibs.re.kr/handle/8788114/11152
DOI
10.1016/j.neuroimage.2021.118844
ISSN
1053-8119
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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