BROWSE

Related Scientist

Koh, Gou Young's photo.

Koh, Gou Young
혈관 연구단
more info

ITEM VIEW & DOWNLOAD

Antiangiogenesis: Vessel Regression, Vessel Normalization, or Both?

Cited 0 time in webofscience Cited 0 time in scopus
199 Viewed 0 Downloaded
Title
Antiangiogenesis: Vessel Regression, Vessel Normalization, or Both?
Author(s)
Augustin, Hellmut G.; Gou Young Koh
Publication Date
2022-01
Journal
Cancer Research, v.82, no.1, pp.15 - 17
Publisher
American Association for Cancer Research Inc.
Abstract
Ó2022 American Association for Cancer ResearchThe concepts of antiangiogenic tumor therapy were pioneered on the assumption that the inhibition of tumor angiogenesis should lead to the complete regression of the tumor-associated vasculature and thereby hold the tumor in an avascular dormant state. Yet, clinical trials revealed limited efficacy of angiogenesis inhibitors when used as monotherapy. Instead, antiangiogenic drugs proved effective to extend overall survival when used in combination with chemotherapy. This counterintuitive observation—inhibition of tumor vascularization should lead to less and not more delivery of chemotherapy to the tumor—led to the concepts of “vessel normalization.” This refers to the notion that antiangiogenic drugs prune the most immature tumor vessels and spare mature vessels, thereby resulting in a more normal-appearing vasculature that leads to better access of chemotherapy to the tumor. The concepts of vessel normalization were first laid out in a landmark publication in Cancer Research in 2004. More than 600 studies on different aspects of vessel normalization have been published since then. Nevertheless, it is to this day less clear than ever to what extent vessel regression (leading to tumor starvation) and vessel normalization (facilitating chemotherapy) contribute to the clinical efficacy of antiangiogenic tumor therapy. This “Landmark Commentary” puts the concepts of tumor vessel normalization in historical context and develops thereupon some of the most burning questions in the field of translational angiogenesis research that need to be answered to further advance the application of tumor vascular stroma reprogramming therapies.
URI
https://pr.ibs.re.kr/handle/8788114/11113
DOI
10.1158/0008-5472.CAN-21-3515
ISSN
0008-5472
Appears in Collections:
Center for Vascular Research(혈관 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse