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Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles

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Title
Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles
Author(s)
Jiuk Jang; Joohee Kim; Haein Shin; Young-Geun Park; Byung Jun Joo; Hunkyu Seo; Jong-eun Won; Dai Woo Kim; Chang Young Lee; Kim, Hong Kyun; Park, Jang-Ung
Publication Date
2021-03
Journal
SCIENCE ADVANCES, v.7, no.14, pp.1 - 10
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution.
URI
https://pr.ibs.re.kr/handle/8788114/11071
DOI
10.1126/sciadv.abf7194
ISSN
2375-2548
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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