BROWSE

Related Scientist

CN's photo.

CN
나노의학 연구단
more info

ITEM VIEW & DOWNLOAD

Reconstruction of Muscle Fascicle-Like Tissues by Anisotropic 3D Patterning

DC Field Value Language
dc.contributor.authorYoonhee Jin-
dc.contributor.authorEun Je Jeon-
dc.contributor.authorSohyeon Jeong-
dc.contributor.authorSungjin Min-
dc.contributor.authorYi Sun Choi-
dc.contributor.authorSo Hyun Kim-
dc.contributor.authorJung Seung Lee-
dc.contributor.authorJisoo Shin-
dc.contributor.authorJi Hea Yu-
dc.contributor.authorDa-Hee Ahn-
dc.contributor.authorYun-Gon Kim-
dc.contributor.authorHee Seok Yang-
dc.contributor.authorTaek Jin Kang-
dc.contributor.authorSung-Rae Cho-
dc.contributor.authorNakwon Choi-
dc.contributor.authorSeung-Woo Cho-
dc.date.accessioned2022-01-10T04:30:13Z-
dc.date.available2022-01-10T04:30:13Z-
dc.date.created2021-05-27-
dc.date.issued2021-06-
dc.identifier.issn1616-301X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11067-
dc.description.abstract© 2021 Wiley-VCH GmbHTissue engineering of skeletal muscle has been proposed as a potential regenerative treatment for extensive muscle damage. In this regard, the highly organized structure of skeletal muscles makes the alignment of cells especially indispensable in muscle tissue engineering. However, achieving the desired alignment continues to prove challenging, particularly in 3D engineered tissue constructs. In this study, a biomimetic approach for the generation of functional skeletal muscle fascicle-like tissues by recapitulating 3D muscle-like cellular and extracellular organization, is demonstrated. Anisotropic 3D alignment of muscle extracellular matrix (MEM) nanofibrils capable of providing a pro-myogenic microenvironment by regulating the kinetics of fibrillogenesis in a stretchable elastomeric chip, is achieved. Reprogrammed muscle progenitor cells develop myofibers along the aligned MEM nanofibrils in a 3D configuration, culminating in the structural and functional maturation of skeletal muscle. The resultant 3D muscle fascicle-like constructs support de novo muscle regeneration and induce functional restoration of injured muscles in animal models inflicted with volumetric muscle loss and congenital muscular dystrophy. This study not only highlights the fundamental roles of the muscle–mimetic structural guidance cues for 3D muscle tissue engineering, but also unveils the clinical potential of artificial muscle constructs in regenerative medicine.-
dc.language영어-
dc.publisherJohn Wiley and Sons Inc-
dc.titleReconstruction of Muscle Fascicle-Like Tissues by Anisotropic 3D Patterning-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000638679000001-
dc.identifier.scopusid2-s2.0-85104112946-
dc.identifier.rimsid75697-
dc.contributor.affiliatedAuthorSeung-Woo Cho-
dc.identifier.doi10.1002/adfm.202006227-
dc.identifier.bibliographicCitationAdvanced Functional Materials, v.31, no.25-
dc.relation.isPartOfAdvanced Functional Materials-
dc.citation.titleAdvanced Functional Materials-
dc.citation.volume31-
dc.citation.number25-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordPlusCELL-CELL CONTACT-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusEXTRACELLULAR-MATRIX-
dc.subject.keywordPlusSTEM-CELLS-
dc.subject.keywordPlusHISTONE H1-
dc.subject.keywordPlusINTEGRIN ALPHA-7-BETA-1-
dc.subject.keywordPlusMYOTENDINOUS JUNCTIONS-
dc.subject.keywordPlusDYSTROPHIC MUSCLE-
dc.subject.keywordPlusBIOLOGIC SCAFFOLD-
dc.subject.keywordPlusMYOBLAST FUSION-
dc.subject.keywordAuthoranisotropic 3D patterning-
dc.subject.keywordAuthordirect reprogramming-
dc.subject.keywordAuthorinduced skeletal muscle progenitor cells-
dc.subject.keywordAuthormuscle extracellular matrix-
dc.subject.keywordAuthormuscle regeneration-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse