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Coordinate regulation of the senescent state by selective autophagy

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Title
Coordinate regulation of the senescent state by selective autophagy
Author(s)
Lee, Yeonghyeon; Kim, Jaejin; Kim, Mi-Sung; Kwon, Yoojin; Sanghee Shin; Hyerim Yi; Hyeonkyeong Kim; Chang, Moon Jong; Chang, Chong Bum; Kang, Seung-Baik; V. Narry Kim; Jin-Hong Kim; Jong-Seo Kim; Elledge, Stephen J.; Kang, Chanhee
Publication Date
2021-05-17
Journal
DEVELOPMENTAL CELL, v.56, no.10, pp.1512 - 1525
Publisher
CELL PRESS
Abstract
Cellular senescence is a complex stress response implicated in aging. Autophagy can suppress senescence but is counterintuitively necessary for full senescence. Although its anti-senescence role is well described, to what extent autophagy contributes to senescence establishment and the underlying mechanisms is poorly understood. Here, we show that selective autophagy of multiple regulatory components coordinates the homeostatic state of senescence. We combined a proteomic analysis of autophagy components with protein stability profiling, identifying autophagy substrate proteins involved in several senescence-related processes. Selective autophagy of KEAP1 promoted redox homeostasis during senescence. Furthermore, selective autophagy limited translational machinery components to ameliorate senescence-associated proteotoxic stress. Lastly, selective autophagy of TNIP1 enhanced senescence-associated inflammation. These selective autophagy networks appear to operate in vivo senescence during human osteoarthritis. Our data highlight a caretaker role of autophagy in the stress support network of senescence through regulated protein stability and unravel the intertwined relationship between two important age-related processes.
URI
https://pr.ibs.re.kr/handle/8788114/10977
DOI
10.1016/j.devcel.2021.04.008
ISSN
1534-5807
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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