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Myung, Kyung Jae
유전체 항상성 연구단
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Thrap3 promotes R-loop resolution via interaction with methylated DDX5

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dc.contributor.authorKang, Hyun Je-
dc.contributor.authorEom, Hye-jin-
dc.contributor.authorKim, Hongtae-
dc.contributor.authorKyungjae Myung-
dc.contributor.authorKwon, Hyug Moo-
dc.contributor.authorChoi, Jang Hyun-
dc.date.accessioned2021-11-16T04:30:00Z-
dc.date.available2021-11-16T04:30:00Z-
dc.date.created2021-11-08-
dc.date.issued2021-10-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10680-
dc.description.abstract© 2021, The Author(s).Transcription-replication conflicts lead to DNA damage and genomic instability, which are closely related to human diseases. A major source of these conflicts is the formation of R-loops, which consist of an RNA-DNA hybrid and a displaced single-stranded DNA. Although these structures have been studied, many aspects of R-loop biology and R-loop-mediated genome instability remain unclear. Here, we demonstrate that thyroid hormone receptor-associated protein 3 (Thrap3) plays a critical role in regulating R-loop resolution. In cancer cells, Thrap3 interacts with DEAD-box helicase 5 (DDX5) and localizes to R-loops. Arginine-mediated methylation of DDX5 is required for its interaction with Thrap3, and the Thrap3-DDX5 axis induces the recruitment of 5’-3’ exoribonuclease 2 (XRN2) into R-loops. Loss of Thrap3 increases R-loop accumulation and DNA damage. These findings suggest that Thrap3 mediates resistance to cell death by preventing R-loop accumulation in cancer cells.-
dc.language영어-
dc.publisherSpringer Nature-
dc.titleThrap3 promotes R-loop resolution via interaction with methylated DDX5-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000710909200001-
dc.identifier.scopusid2-s2.0-85117940667-
dc.identifier.rimsid76691-
dc.contributor.affiliatedAuthorKyungjae Myung-
dc.identifier.doi10.1038/s12276-021-00689-6-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, v.53, no.10, pp.1602 - 1611-
dc.relation.isPartOfExperimental and Molecular Medicine-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.volume53-
dc.citation.number10-
dc.citation.startPage1602-
dc.citation.endPage1611-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusRNA-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusREGULATORS-
dc.subject.keywordPlusTHREATS-
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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