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Lee, Yoon Sung
유전체 항상성 연구단
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SOCS3 is Related to Cell Proliferation in Neuronal Tissue: An Integrated Analysis of Bioinformatics and Experiments

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Title
SOCS3 is Related to Cell Proliferation in Neuronal Tissue: An Integrated Analysis of Bioinformatics and Experiments
Author(s)
Yu, Yeuni; Sung, Soon Ki; Lee, Chi Hyung; Ha, Mihyang; Kang, Junho; Kwon, Eun Jung; Kang, Ji Wan; Kim, Youngjoo; Kim, Ga Hyun; Heo, Hye Jin; Lee, Hansong; Kim, Tae Woo; Yoonsung Lee; Kyungjae Myung; Chang-Kyu Oh; Kim, Yun Hak
Publication Date
2021-09-27
Journal
Frontiers in Genetics, v.12
Publisher
Frontiers Media S.A.
Abstract
© Copyright © 2021 Yu, Sung, Lee, Ha, Kang, Kwon, Kang, Kim, Kim, Heo, Lee, Kim, Lee, Myung, Oh and Kim.Glioma is the most common primary malignant tumor that occurs in the central nervous system. Gliomas are subdivided according to a combination of microscopic morphological, molecular, and genetic factors. Glioblastoma (GBM) is the most aggressive malignant tumor; however, efficient therapies or specific target molecules for GBM have not been developed. We accessed RNA-seq and clinical data from The Cancer Genome Atlas, the Chinese Glioma Genome Atlas, and the GSE16011 dataset, and identified differentially expressed genes (DEGs) that were common to both GBM and lower-grade glioma (LGG) in three independent cohorts. The biological functions of common DEGs were examined using NetworkAnalyst. To evaluate the prognostic performance of common DEGs, we performed Kaplan-Meier and Cox regression analyses. We investigated the function of SOCS3 in the central nervous system using three GBM cell lines as well as zebrafish embryos. There were 168 upregulated genes and 50 downregulated genes that were commom to both GBM and LGG. Through survival analyses, we found that SOCS3 was the only prognostic gene in all cohorts. Inhibition of SOCS3 using siRNA decreased the proliferation of GBM cell lines. We also found that the zebrafish ortholog, socs3b, was associated with brain development through the regulation of cell proliferation in neuronal tissue. While additional mechanistic studies are necessary, our results suggest that SOCS3 is an important biomarker for glioma and that SOCS3 is related to the proliferation of neuronal tissue.
URI
https://pr.ibs.re.kr/handle/8788114/10678
DOI
10.3389/fgene.2021.743786
ISSN
1664-8021
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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