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Kim, Vic Narry
RNA 연구단
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The regulatory impact of RNA-binding proteins on microRNA targeting

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Title
The regulatory impact of RNA-binding proteins on microRNA targeting
Author(s)
Kim, Sukjun; Kim, Soyoung; Chang, Hee Ryung; Kim, Doyeon; Park, Junehee; Son, Narae; Park, Joori; Yoon, Minhyuk; Chae, Gwangung; Kim, Young-Kook; V. Narry Kim; Kim, Yoon Ki; Nam, Jin-Wu; Shin, Chanseok; Baek, Daehyun
Publication Date
2021-12
Journal
Nature Communications, v.12, no.1
Publisher
Nature Research
Abstract
© 2021, The Author(s).Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently identified >1,500 human RNA-binding proteins (RBPs), there are only a handful of RBPs known to enhance MT and several others reported to suppress MT, leaving the global impact of RBPs on MT elusive. In this study, we have systematically analyzed transcriptome-wide binding sites for 150 human RBPs and evaluated the quantitative effect of individual RBPs on MT efficacy. In contrast to previous studies, we show that most RBPs significantly affect MT and that all of those MT-regulating RBPs function as MT enhancers rather than suppressors, by making the local secondary structure of the target site accessible to Argonaute. Our findings illuminate the unappreciated regulatory impact of human RBPs on MT, and as these RBPs may play key roles in the gene regulatory network governed by metazoan miRNAs, MT should be understood in the context of co-regulating RBPs.
URI
https://pr.ibs.re.kr/handle/8788114/10547
DOI
10.1038/s41467-021-25078-5
ISSN
2041-1723
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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