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Kolygina, Diana
첨단연성물질 연구단
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Mixed-Charge Nanocarriers Allow for Selective Targeting of Mitochondria by Otherwise Nonselective Dyes

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dc.contributor.authorDiana V. Kolygina-
dc.contributor.authorMarta Siek-
dc.contributor.authorMagdalena Borkowska-
dc.contributor.authorGuillermo Ahumada-
dc.contributor.authorBarski, Piotr-
dc.contributor.authorWitt, Dariusz-
dc.contributor.authorAh-Young Jee-
dc.contributor.authorHan Miao-
dc.contributor.authorJuan Carlos Ahumada-
dc.contributor.authorSteve Granick-
dc.contributor.authorKristiana Kandere-Grzybowska-
dc.contributor.authorBartosz A. Grzybowski-
dc.date.accessioned2021-10-28T01:27:59Z-
dc.date.available2021-10-28T01:27:59Z-
dc.date.created2021-08-09-
dc.date.issued2021-07-27-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10513-
dc.description.abstract© 2021 American Chemical Society.Targeted delivery of molecular cargos to specific organelles is of paramount importance for developing precise and effective therapeutics and imaging probes. This work describes a disulfide-based delivery method in which mixed-charged nanoparticles traveling through the endolysosomal tract deliver noncovalently bound dye molecules selectively into mitochondria. This system comprises three elements: (1) The nanoparticles deliver their payloads by a kiss-and-go mechanism-that is, they drop off their dye cargos proximate to mitochondria but do not localize therein; (2) the dye molecules are by themselves nonspecific to any cellular structures but become so with the help of mixed-charge nanocarriers; and (3) the dye is engineered in such a way as to remain in mitochondria for a long time, up to days, allowing for observing dynamic remodeling of mitochondrial networks and long-term tracking of mitochondria even in dividing cells. The selectivity of delivery and long-lasting staining derive from the ability to engineer charge-imbalanced, mixed [+/-] on-particle monolayers and from the structural features of the cargo. Regarding the former, the balance of [+] and [-] ligands can be adjusted to limit cytotoxicity and control the number of dye molecules adsorbed onto the particles' surfaces. Regarding the latter, comparative studies with multiple dye derivatives we synthesized rationalize the importance of polar groups, long alkyl chains, and disulfide moieties in the assembly of fluorescent nanoconstructs and long-lasting staining of mitochondria. Overall, this strategy could be useful for delivering hydrophilic and/or anionic small-molecule drugs difficult to target to mitochondria by classical approaches.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleMixed-Charge Nanocarriers Allow for Selective Targeting of Mitochondria by Otherwise Nonselective Dyes-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000679406500044-
dc.identifier.scopusid2-s2.0-85110430084-
dc.identifier.rimsid76177-
dc.contributor.affiliatedAuthorDiana V. Kolygina-
dc.contributor.affiliatedAuthorMarta Siek-
dc.contributor.affiliatedAuthorMagdalena Borkowska-
dc.contributor.affiliatedAuthorGuillermo Ahumada-
dc.contributor.affiliatedAuthorAh-Young Jee-
dc.contributor.affiliatedAuthorHan Miao-
dc.contributor.affiliatedAuthorJuan Carlos Ahumada-
dc.contributor.affiliatedAuthorSteve Granick-
dc.contributor.affiliatedAuthorKristiana Kandere-Grzybowska-
dc.contributor.affiliatedAuthorBartosz A. Grzybowski-
dc.identifier.doi10.1021/acsnano.1c01232-
dc.identifier.bibliographicCitationACS NANO, v.15, no.7, pp.11470 - 11490-
dc.relation.isPartOfACS NANO-
dc.citation.titleACS NANO-
dc.citation.volume15-
dc.citation.number7-
dc.citation.startPage11470-
dc.citation.endPage11490-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusGOLD NANOPARTICLES-
dc.subject.keywordPlusCELLULAR UPTAKE-
dc.subject.keywordPlusFLUORESCENCE PROPERTIES-
dc.subject.keywordPlusLIGAND-EXCHANGE-
dc.subject.keywordPlusLIVING CELLS-
dc.subject.keywordPlusMEMBRANE-
dc.subject.keywordPlusTHIOLS-
dc.subject.keywordPlusCONJUGATION-
dc.subject.keywordPlusABSORPTION-
dc.subject.keywordPlusORGANELLES-
dc.subject.keywordAuthorfluorescein disulfide-
dc.subject.keywordAuthormitochondrial targeting-
dc.subject.keywordAuthormixed-charge nanoparticles-
dc.subject.keywordAuthornanocarriers-
dc.subject.keywordAuthorfluorescent probe-
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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