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Shape-dependent intracellular uptake of metal–organic framework nanoparticles

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Title
Shape-dependent intracellular uptake of metal–organic framework nanoparticles
Author(s)
Kim, Se-Na; Chun Gwon Park; Min, Chang Hee; Lee, Seung Ho; Lee, Yun Young; Lee, Na Kyeong; Choy, Young Bin
Publication Date
2021-01-01
Journal
Journal of Industrial and Engineering Chemistry, v.104, no.25, pp.468 - 477
Publisher
Korean Society of Industrial Engineering Chemistry
Abstract
© 2021 The Korean Society of Industrial and Engineering ChemistryMetal–organic framework (MOF) nanoparticles are promising carriers for the internal delivery of therapeutics to the cells; however, the effects of their shape on cellular uptake have not yet been clearly evaluated. Therefore, we synthesized biocompatible Fe-based MOF nanoparticles of two distinct shapes—rods and octahedrons (NH2-MIL-88B(Fe)-ROD and NH2-MIL-88B(Fe)-OCTA, respectively)—and evaluated their cellular uptake kinetics and mechanisms using three different cell lines (HeLa, MDA-MB-231, and L929). Although both nanoparticles possessed the same constituent metal, organic linkers, and thus, crystalline structures, a more rapid uptake was observed with NH2-MIL-88B(Fe)-OCTA, whereas NH2-MIL-88B(Fe)-ROD were endocytosed in a more sustained manner. This could be ascribed to the large number of sharp edges available in NH2-MIL-88B(Fe)-OCTA particles; hence, there were more points of expedited entry into the cells via a clathrin-mediated pathway. The findings herein provide important information for the application of the MOF nanoparticles as intracellular drug delivery carriers, especially when they can be prepared in different shapes with the same composition.
URI
https://pr.ibs.re.kr/handle/8788114/10411
DOI
10.1016/j.jiec.2021.08.042
ISSN
1226-086X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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