BROWSE

Related Scientist

CVR's photo.

CVR
혈관 연구단
more info

ITEM VIEW & DOWNLOAD

Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour

Cited 0 time in webofscience Cited 0 time in scopus
18 Viewed 0 Downloaded
Title
Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
Author(s)
Jeong, Seung-hwan; Myung Jin Yang; Seunghyeok Choi; JungMo Kim; Gou Young Koh
Publication Date
2021-07
Journal
Nature Communications, v.12, no.1
Publisher
Nature Research
Abstract
© 2021, The Author(s).Stimulator of interferon genes (STING) promotes anti-tumour immunity by linking innate and adaptive immunity, but it remains unclear how intratumoural treatment with STING agonists yields anti-tumour effects. Here we demonstrate that intratumoural injection of the STING agonist cGAMP induces strong, rapid, and selective apoptosis of tumour endothelial cells (ECs) in implanted LLC tumour, melanoma and breast tumour, but not in spontaneous breast cancer and melanoma. In both implanted and spontaneous tumours, cGAMP greatly increases TNFα from tumour-associated myeloid cells. However, compared to spontaneous tumour ECs, implanted tumour ECs are more vulnerable to TNFα-TNFR1 signalling-mediated apoptosis, which promotes effective anti-tumour activity. The spontaneous tumour’s refractoriness to cGAMP is abolished by co-treatment with AKT 1/2 inhibitor (AKTi). Combined treatment with cGAMP and AKTi induces extensive tumour EC apoptosis, leading to extensive tumour apoptosis and marked growth suppression of the spontaneous tumour. These findings propose an advanced avenue for treating primary tumours that are refractory to single STING agonist therapy.
URI
https://pr.ibs.re.kr/handle/8788114/10337
DOI
10.1038/s41467-021-24603-w
ISSN
2041-1723
Appears in Collections:
Center for Vascular Research(혈관 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse