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시냅스 뇌질환 연구단
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Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

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Title
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice
Author(s)
Eunee Lee; Seungjoon Lee; Jae Jin Shin; Choi, Woochul; Changuk Chung; Lee, Suho; Jihye Kim; Seungmin Ha; Ryunhee Kim; Taesun Yoo; Yoo, Ye-Eun; Kim, Jisoo; Noh, Young Woo; Issac Rhim; Lee, Soo Yeon; Kim, Woohyun; Taekyung Lee; Shin, Hyogeun; Cho, Il-Joo; Deisseroth, Karl; Kim, Sang Jeong; Park, Joo Min; Min Whan Jung; Paik, Se-Bum; Eunjoon Kim
Publication Date
2021-08
Journal
NATURE COMMUNICATIONS, v.12, no.1
Publisher
Nature Research
Abstract
© 2021, The Author(s).NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here that NMDARs in cortical parvalbumin (Pv)-positive interneurons cooperate with gap junctions to promote high-frequency (>80 Hz) Pv neuronal burst firing and social cognition. Shank2–/– mice, displaying improved sociability upon NMDAR activation, show impaired cortical social representation and inhibitory neuronal burst firing. Cortical Shank2–/– Pv neurons show decreased NMDAR activity, which suppresses the cooperation between NMDARs and gap junctions (GJs) for normal burst firing. Shank2–/– Pv neurons show compensatory increases in GJ activity that are not sufficient for social rescue. However, optogenetic boosting of Pv neuronal bursts, requiring GJs, rescues cortical social cognition in Shank2–/– mice, similar to the NMDAR-dependent social rescue. Therefore, NMDARs and gap junctions cooperate to promote cortical Pv neuronal bursts and social cognition.
URI
https://pr.ibs.re.kr/handle/8788114/10334
DOI
10.1038/s41467-021-25356-2
ISSN
2041-1723
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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