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Graphene oxide for fluorescence-mediated enzymatic activity assays

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Title
Graphene oxide for fluorescence-mediated enzymatic activity assays
Author(s)
Hongje Jang; Jieon Lee; Dal-Hee Min
Publication Date
2014-05
Journal
JOURNAL OF MATERIALS CHEMISTRY B, v.2, no.17, pp.2452 - 2460
Publisher
ROYAL SOC CHEMISTRYROYAL SOC CHEMISTRY
Abstract
Graphene oxide (GO), an oxidized 2-dimensional carbon material, has been studied actively in both academia and industry due to its unique physicochemical properties including high surface area, excellent aqueous dispersibility, quenching capability of contiguous fluorophores and adsorption affinity with diverse biomolecules. Particularly, GO has been widely used in biological applications involving small molecule biosensors, enzymatic reaction monitoring, drug delivery and therapeutic applications. Among these rapidly developing fields, we focused on the current advancements of fluorescence mediated activity assay platforms for enzymes including nucleases, methyltransferases, protein kinases, caspases and helicases by using affinity and fluorescence quenching capability of GO with fluorophore labelled biomolecule substrates in the aqueous solution phase, and its important applications with future perspectives in this article.
URI
https://pr.ibs.re.kr/handle/8788114/1032
ISSN
2050-750X
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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