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Kim, Tai Young
인지 및 사회성 연구단
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Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

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dc.contributor.authorTai Young Kim-
dc.contributor.authorJeon, Sangeun-
dc.contributor.authorJang, Youngho-
dc.contributor.authorGotina, Lizaveta-
dc.contributor.authorJoungha Won-
dc.contributor.authorYeon Ha Ju-
dc.contributor.authorSunpil Kim-
dc.contributor.authorMinwoo Wendy Jang-
dc.contributor.authorWoojin Won-
dc.contributor.authorMingu Gordon Park-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorHan, Sunkyu-
dc.contributor.authorKim, Seungtaek-
dc.contributor.authorC. Justin Lee-
dc.date.accessioned2021-07-09T02:50:08Z-
dc.date.accessioned2021-07-09T02:50:08Z-
dc.date.available2021-07-09T02:50:08Z-
dc.date.available2021-07-09T02:50:08Z-
dc.date.created2021-07-07-
dc.date.issued2021-05-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9888-
dc.description.abstract© 2021, The Author(s).An ongoing pandemic of coronavirus disease 2019 (COVID-19) is now the greatest threat to global public health. Herbal medicines and their derived natural products have drawn much attention in the treatment of COVID-19, but the detailed mechanisms by which natural products inhibit SARS-CoV-2 have not been elucidated. Here, we show that platycodin D (PD), a triterpenoid saponin abundant in Platycodon grandiflorum (PG), a dietary and medicinal herb commonly used in East Asia, effectively blocks the two main SARS-CoV-2 infection routes via lysosome- and transmembrane protease serine 2 (TMPRSS2)-driven entry. Mechanistically, PD prevents host entry of SARS-CoV-2 by redistributing membrane cholesterol to prevent membrane fusion, which can be reinstated by treatment with a PD-encapsulating agent. Furthermore, the inhibitory effects of PD are recapitulated by the pharmacological inhibition or gene silencing of NPC1, which is mutated in patients with Niemann–Pick type C (NPC) displaying disrupted membrane cholesterol distribution. Finally, readily available local foods or herbal medicines containing PG root show similar inhibitory effects against SARS-CoV-2 infection. Our study proposes that PD is a potent natural product for preventing or treating COVID-19 and that briefly disrupting the distribution of membrane cholesterol is a potential novel therapeutic strategy for SARS-CoV-2 infection.-
dc.description.uri1-
dc.language영어-
dc.publisherSpringer Nature-
dc.titlePlatycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000654095700002-
dc.identifier.scopusid2-s2.0-85106443095-
dc.identifier.rimsid75990-
dc.contributor.affiliatedAuthorTai Young Kim-
dc.contributor.affiliatedAuthorJoungha Won-
dc.contributor.affiliatedAuthorYeon Ha Ju-
dc.contributor.affiliatedAuthorSunpil Kim-
dc.contributor.affiliatedAuthorMinwoo Wendy Jang-
dc.contributor.affiliatedAuthorWoojin Won-
dc.contributor.affiliatedAuthorMingu Gordon Park-
dc.contributor.affiliatedAuthorC. Justin Lee-
dc.identifier.doi10.1038/s12276-021-00624-9-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, v.53, no.5, pp.956 - 972-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.volume53-
dc.citation.number5-
dc.citation.startPage956-
dc.citation.endPage972-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusBETA-CYCLODEXTRIN-
dc.subject.keywordPlusCHOLESTEROL-
dc.subject.keywordPlusCOVID-19-
dc.subject.keywordPlusGLYCYRRHIZIN-
dc.subject.keywordPlusREPLICATION-
dc.subject.keywordPlusINHIBIT-
dc.subject.keywordPlusVIRUS-
dc.subject.keywordPlusACE2-
dc.subject.keywordAuthorBETA-CYCLODEXTRIN-
dc.subject.keywordAuthorCHOLESTEROL-
dc.subject.keywordAuthorCOVID-19-
dc.subject.keywordAuthorGLYCYRRHIZIN-
dc.subject.keywordAuthorREPLICATION-
dc.subject.keywordAuthorINHIBIT-
dc.subject.keywordAuthorVIRUS-
dc.subject.keywordAuthorACE2-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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