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인지 및 사회성 연구단
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Tumor spheroids of an aggressive form of central neurocytoma have transit-amplifying progenitor characteristics with enhanced EGFR and tumor stem cell signaling

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dc.contributor.authorShin, Hye Young-
dc.contributor.authorCCS-
dc.contributor.authorPark, Hyung Woo-
dc.contributor.authorHong, Yun Hwa-
dc.contributor.authorKim, Yona-
dc.contributor.authorMoon, Hyo Eun-
dc.contributor.authorPark, Kwang Woo-
dc.contributor.authorPark, Hye Ran-
dc.contributor.authorC. Justin Lee-
dc.contributor.authorLee, Kiyoung-
dc.contributor.authorKim, Sang Jeong-
dc.contributor.authorHeo, Man Seung-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorKim, Dong Gyu-
dc.contributor.authorPaek, Sun Ha-
dc.date.accessioned2021-07-09T00:50:01Z-
dc.date.accessioned2021-07-09T00:50:01Z-
dc.date.available2021-07-09T00:50:01Z-
dc.date.available2021-07-09T00:50:01Z-
dc.date.created2021-07-07-
dc.date.issued2021-04-
dc.identifier.issn1226-2560-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9886-
dc.description.abstract©opyright © Experimental Neurobiology 2021.Central neurocytoma (CN) has been known as a benign neuronal tumor. In rare cases, CN undergoes malignant transformation to glioblastomas (GBM). Here we examined its cellular origin by characterizing differentiation potential and gene expression of CN-spheroids. First, we demonstrate that both CN tissue and cultured primary cells recapitulate the hierarchal cellular composition of subventricular zone (SVZ), which is comprised of neural stem cells (NSCs), transit amplifying progenitors (TAPs), and neuroblasts. We then derived spheroids from CN which displayed EGFR+/ MASH+ TAP and BLBP+ radial glial cell (RGC) characteristic, and mitotic neurogenesis and gliogenesis by single spheroids were observed with cycling multipotential cells. CN-spheroids expressed increased levels of pluripotency and tumor stem cell genes such as KLF4 and TPD5L1, when compared to their differentiated cells and human NSCs. Importantly, Gene Set Enrichment Analysis showed that gene sets of GBM-Spheroids, EGFR Signaling, and Packaging of Telomere Ends are enriched in CN-spheroids in comparison with their differentiated cells. We speculate that CN tumor stem cells have TAP and RGC characteristics, and upregulation of EGFR signaling as well as downregulation of eph-ephrin signaling have critical roles in tumorigenesis of CN. And their ephemeral nature of TAPs destined to neuroblasts, might reflect benign nature of CN.-
dc.description.uri1-
dc.language영어-
dc.publisherKorean Society for Neurodegenerative Disease-
dc.titleTumor spheroids of an aggressive form of central neurocytoma have transit-amplifying progenitor characteristics with enhanced EGFR and tumor stem cell signaling-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000654000200003-
dc.identifier.scopusid2-s2.0-85106705989-
dc.identifier.rimsid75997-
dc.contributor.affiliatedAuthorCCS-
dc.contributor.affiliatedAuthorC. Justin Lee-
dc.identifier.doi10.5607/EN21004-
dc.identifier.bibliographicCitationExperimental Neurobiology, v.30, no.2, pp.120 - 143-
dc.citation.titleExperimental Neurobiology-
dc.citation.volume30-
dc.citation.number2-
dc.citation.startPage120-
dc.citation.endPage143-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusGENE-EXPRESSION PROFILES-
dc.subject.keywordPlusSUBVENTRICULAR ZONE-
dc.subject.keywordPlusGROWTH-FACTOR-
dc.subject.keywordPlusLINEAGE PROGRESSION-
dc.subject.keywordPlusRADIAL GLIA-
dc.subject.keywordPlusDIFFERENTIAL EXPRESSION-
dc.subject.keywordPlusNEURAL PROGENITORS-
dc.subject.keywordPlusHUMAN BRAIN-
dc.subject.keywordPlusE-CADHERIN-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordAuthorGene Set Enrichment Analysis-
dc.subject.keywordAuthorNeural stem cell-
dc.subject.keywordAuthorRadial glia cells-
dc.subject.keywordAuthorSubventricular zone-
dc.subject.keywordAuthorTransit-amplifying cells-
dc.subject.keywordAuthorTumor spheroids-
dc.subject.keywordAuthorCentral neurocytoma-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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