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Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions

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dc.contributor.authorKiwon Park-
dc.contributor.authorRyoo, Jeongmin-
dc.contributor.authorHeena Jeong-
dc.contributor.authorMinsu Kim-
dc.contributor.authorSungwon Lee-
dc.contributor.authorSungYeon Hwang-
dc.contributor.authorAhn, Jiyoung-
dc.contributor.authorKim, Doyeon-
dc.contributor.authorMoon, Hyungseok C.-
dc.contributor.authorBaek, Daehyun-
dc.contributor.authorKim, Kwangsoo-
dc.contributor.authorPark, Hye Yoon-
dc.contributor.authorKwangseog Ahn-
dc.date.accessioned2021-07-06T05:30:06Z-
dc.date.accessioned2021-07-06T05:30:06Z-
dc.date.available2021-07-06T05:30:06Z-
dc.date.available2021-07-06T05:30:06Z-
dc.date.created2021-05-27-
dc.date.issued2021-04-
dc.identifier.issn1553-7390-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9856-
dc.description.abstract© 2021 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The comorbid association of autoimmune diseases with cancers has been a major obstacle to successful anti-cancer treatment. Cancer survival rate decreases significantly in patients with preexisting autoimmunity. However, to date, the molecular and cellular profiles of such comorbidities are poorly understood. We used Aicardi-Goutières syndrome (AGS) as a model autoimmune disease and explored the underlying mechanisms of genome instability in AGS-associated-gene-deficient patient cells. We found that R-loops are highly enriched at transcription-replication conflict regions of the genome in fibroblast of patients bearing SAMHD1 mutation, which is the AGS-associated-gene mutation most frequently reported with tumor and malignancies. In SAMHD1-depleted cells, R-loops accumulated with the concomitant activation of DNA damage responses. Removal of R-loops in SAMHD1 deficiency reduced cellular responses to genome instability. Furthermore, downregulation of SAMHD1 expression is associated with various types of cancer and poor survival rate. Our findings suggest that SAMHD1 functions as a tumor suppressor by resolving R-loops, and thus, SAMHD1 and R-loop may be novel diagnostic markers and targets for patient stratification in anti-cancer therapy.-
dc.description.uri1-
dc.language영어-
dc.publisherPublic Library of Science-
dc.titleAicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000640606700002-
dc.identifier.scopusid2-s2.0-85104964777-
dc.identifier.rimsid75661-
dc.contributor.affiliatedAuthorKiwon Park-
dc.contributor.affiliatedAuthorHeena Jeong-
dc.contributor.affiliatedAuthorMinsu Kim-
dc.contributor.affiliatedAuthorSungwon Lee-
dc.contributor.affiliatedAuthorSungYeon Hwang-
dc.contributor.affiliatedAuthorKwangseog Ahn-
dc.identifier.doi10.1371/journal.pgen.1009523-
dc.identifier.bibliographicCitationPLoS Genetics, v.17, no.4-
dc.citation.titlePLoS Genetics-
dc.citation.volume17-
dc.citation.number4-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryGenetics & Heredity-
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Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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