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RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis

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dc.contributor.authorHyunjoon Kim-
dc.contributor.authorYoung-suk Lee-
dc.contributor.authorKim, Seok-Min-
dc.contributor.authorSoohyun Jang-
dc.contributor.authorChoi, Hyunji-
dc.contributor.authorLee, Jae-Won-
dc.contributor.authorKim, Tae-Don-
dc.contributor.authorV. Narry Kim-
dc.date.accessioned2021-07-06T04:50:03Z-
dc.date.accessioned2021-07-06T04:50:04Z-
dc.date.available2021-07-06T04:50:03Z-
dc.date.available2021-07-06T04:50:04Z-
dc.date.created2021-05-27-
dc.date.issued2021-04-
dc.identifier.issn1534-5807-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9855-
dc.description.abstract© 2021 Elsevier Inc.Adenosine N6-methylation (m6A) is one of the most pervasive mRNA modifications, and yet the physiological significance of m6A removal (demethylation) remains elusive. Here, we report that the m6A demethylase FTO functions as a conserved regulator of motile ciliogenesis. Mechanistically, FTO demethylates and thereby stabilizes the mRNA that encodes the master ciliary transcription factor FOXJ1. Depletion of Fto in Xenopus laevis embryos caused widespread motile cilia defects, and Foxj1 was identified as one of the major phenocritical targets. In primary human airway epithelium, FTO depletion also led to FOXJ1 mRNA destabilization and a severe loss of ciliated cells with an increase of neighboring goblet cells. Consistently, Fto knockout mice showed strong asthma-like phenotypes upon allergen challenge, a result owing to defective ciliated cells in the airway epithelium. Altogether, our study reveals a conserved role of the FTO-FOXJ1 axis in embryonic and homeostatic motile ciliogenesis.-
dc.description.uri1-
dc.language영어-
dc.publisherCell Press-
dc.titleRNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000641582300006-
dc.identifier.scopusid2-s2.0-85104143343-
dc.identifier.rimsid75681-
dc.contributor.affiliatedAuthorHyunjoon Kim-
dc.contributor.affiliatedAuthorYoung-suk Lee-
dc.contributor.affiliatedAuthorSoohyun Jang-
dc.contributor.affiliatedAuthorV. Narry Kim-
dc.identifier.doi10.1016/j.devcel.2021.03.006-
dc.identifier.bibliographicCitationDevelopmental Cell, v.56, no.8, pp.1118 - 1130.e6-
dc.citation.titleDevelopmental Cell-
dc.citation.volume56-
dc.citation.number8-
dc.citation.startPage1118-
dc.citation.endPage1130.e6-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorairway epithelium-
dc.subject.keywordAuthorasthma-
dc.subject.keywordAuthorFOXJ1-
dc.subject.keywordAuthorFTO-
dc.subject.keywordAuthorm6A-
dc.subject.keywordAuthormotile ciliogenesis-
dc.subject.keywordAuthorN6-methyladenosine-
dc.subject.keywordAuthorRNA modification-
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Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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