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lee,hyunji
유전체교정연구단
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Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

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dc.contributor.authorHyunji Lee-
dc.contributor.authorSeonghyun Lee-
dc.contributor.authorGayoung Baek-
dc.contributor.authorAnnie Kim-
dc.contributor.authorBeum-Chang Kang-
dc.contributor.authorHuiyun Seo-
dc.contributor.authorJin-Soo Kim-
dc.date.accessioned2021-04-19T06:37:46Z-
dc.date.accessioned2021-04-19T06:37:46Z-
dc.date.available2021-04-19T06:37:46Z-
dc.date.available2021-04-19T06:37:46Z-
dc.date.created2021-03-09-
dc.date.issued2021-02-19-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9498-
dc.description.abstractDddA-derived cytosine base editors (DdCBEs), composed of the split interbacterial toxin DddA(tox), transcription activator-like effector (TALE), and uracil glycosylase inhibitor (UGI), enable targeted C-to-T base conversions in mitochondrial DNA (mtDNA). Here, we demonstrate highly efficient mtDNA editing in mouse embryos using custom-designed DdCBEs. We target the mitochondrial gene, MT-ND5 (ND5), which encodes a subunit of NADH dehydrogenase that catalyzes NADH dehydration and electron transfer to ubiquinone, to obtain several mtDNA mutations, including m.G12918A associated with human mitochondrial diseases and m.C12336T that incorporates a premature stop codon, creating mitochondrial disease models in mice and demonstrating a potential for the treatment of mitochondrial disorders. Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.-
dc.language영어-
dc.publisherNATURE RESEARCH-
dc.titleMitochondrial DNA editing in mice with DddA-TALE fusion deaminases-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000621495300002-
dc.identifier.scopusid2-s2.0-85101041088-
dc.identifier.rimsid74893-
dc.contributor.affiliatedAuthorHyunji Lee-
dc.contributor.affiliatedAuthorSeonghyun Lee-
dc.contributor.affiliatedAuthorGayoung Baek-
dc.contributor.affiliatedAuthorAnnie Kim-
dc.contributor.affiliatedAuthorBeum-Chang Kang-
dc.contributor.affiliatedAuthorHuiyun Seo-
dc.contributor.affiliatedAuthorJin-Soo Kim-
dc.identifier.doi10.1038/s41467-021-21464-1-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.12, no.1-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume12-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > 1. Journal Papers (저널논문)
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