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Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells

DC Field Value Language
dc.contributor.authorKim, Chuna-
dc.contributor.authorSung, Sanghyun-
dc.contributor.authorJong-Seo Kim-
dc.contributor.authorLee, Hyunji-
dc.contributor.authorYoonseok Jung-
dc.contributor.authorSanghee Shin-
dc.contributor.authorKim, Eunkyeong-
dc.contributor.authorJenny J. Seo-
dc.contributor.authorKim, Jun-
dc.contributor.authorKim, Daeun-
dc.contributor.authorNiida, Hiroyuki-
dc.contributor.authorV. Narry Kim-
dc.contributor.authorPark, Daechan-
dc.contributor.authorLee, Junho-
dc.date.accessioned2021-04-07T02:30:06Z-
dc.date.accessioned2021-04-07T02:30:06Z-
dc.date.available2021-04-07T02:30:06Z-
dc.date.available2021-04-07T02:30:06Z-
dc.date.created2021-03-11-
dc.date.issued2021-02-17-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9320-
dc.description.abstractTelomeres are part of a highly refined system for maintaining the stability of linear chromosomes. Most telomeres rely on simple repetitive sequences and telomerase enzymes to protect chromosomal ends; however, in some species or telomerase-defective situations, an alternative lengthening of telomeres (ALT) mechanism is used. ALT mainly utilises recombination-based replication mechanisms and the constituents of ALT-based telomeres vary depending on models. Here we show that mouse telomeres can exploit non-telomeric, unique sequences in addition to telomeric repeats. We establish that a specific subtelomeric element, the mouse template for ALT (mTALT), is used for repairing telomeric DNA damage as well as for composing portions of telomeres in ALT-dependent mouse embryonic stem cells. Epigenomic and proteomic analyses before and after ALT activation reveal a high level of non-coding mTALT transcripts despite the heterochromatic nature of mTALT-based telomeres. After ALT activation, the increased HMGN1, a non-histone chromosomal protein, contributes to the maintenance of telomere stability by regulating telomeric transcription. These findings provide a molecular basis to study the evolution of new structures in telomeres. Telomeres can be maintained by a telomerase-independent mechanism called an alternative lengthening of telomeres (ALT). Here the authors use mouse Terc (telomerase RNA) knockout embryonic cells and provide longitudinal analysis of ALT telomeres maintained with non-telomeric sequences.-
dc.language영어-
dc.publisherNATURE RESEARCH-
dc.titleTelomeres reforged with non-telomeric sequences in mouse embryonic stem cells-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000621232800016-
dc.identifier.scopusid2-s2.0-85100884760-
dc.identifier.rimsid75032-
dc.contributor.affiliatedAuthorJong-Seo Kim-
dc.contributor.affiliatedAuthorYoonseok Jung-
dc.contributor.affiliatedAuthorSanghee Shin-
dc.contributor.affiliatedAuthorJenny J. Seo-
dc.contributor.affiliatedAuthorV. Narry Kim-
dc.identifier.doi10.1038/s41467-021-21341-x-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.12, no.1-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume12-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusDNA HYBRIDS-
dc.subject.keywordPlusR-LOOPS-
dc.subject.keywordPlusMAINTENANCE-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlusPROVIDES-
dc.subject.keywordPlusREVEALS-
dc.subject.keywordPlusABSENCE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusREPAIR-
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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