Functional Relationships between the Hippocampus and Dorsomedial Striatum in Learning a Visual Scene-Based Memory Task in Rats

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Title
Functional Relationships between the Hippocampus and Dorsomedial Striatum in Learning a Visual Scene-Based Memory Task in Rats
Author(s)
Sebastien Delcasso; Namjung Huh; Jung Seop Byeon; Jihyun Lee; Min Whan Jung; Inah Lee
Publication Date
2014-11
Journal
JOURNAL OF NEUROSCIENCE, v.34, no.47, pp.15534 - 15547
Publisher
SOC NEUROSCIENCE
Abstract
The hippocampus is important for contextual behavior, and the striatum plays key roles in decision making. When studying the functional relationships with the hippocampus, prior studies have focused mostly on the dorsolateral striatum (DLS), emphasizing the antagonistic relationships between the hippocampus and DLS in spatial versus response learning. By contrast, the functional relationships between the dorsomedial striatum (DMS) and hippocampus are relatively unknown. The current study reports that lesions to both the hippocampus and DMS profoundly impaired performance of rats in a visual scene-based memory task in which the animals were required to make a choice response by using visual scenes displayed in the background. Analysis of simultaneous recordings of local field potentials revealed that the gamma oscillatory power was higher in the DMS, but not in CA1, when the rat performed the task using familiar scenes than novel ones. In addition, the CA1-DMS networks increased coherence at, but not at, rhythm as the rat mastered the task. At the single-unit level, the neuronal populations in CA1 and DMS showed differential firing patterns when responses were made using familiar visual scenes than novel ones. Such learning-dependent firing patterns were observed earlier in theDMSthan inCA1before the rat made choice responses. The present findings suggest that both the hippocampus and DMS process memory representations for visual scenes in parallel with different time courses and that flexible choice action using background visual scenes requires coordinated operations of the hippocampus and DMS at frequencies.
URI
https://pr.ibs.re.kr/handle/8788114/874
ISSN
0270-6474
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
Sebastien D._Functional relationship_J. Neurosci._2014. 11.pdfDownload

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