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유전체교정연구단
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Recent advances in genome editing of stem cells for drug discovery and therapeutic application

DC Field Value Language
dc.contributor.authorJaesuk Lee-
dc.contributor.authorDelger Bayarsaikhan-
dc.contributor.authorGovigerel Bayarsaikhan-
dc.contributor.authorJin-Soo Kim-
dc.contributor.authorElizabeth Schwarzbach-
dc.contributor.authorBonghee Lee-
dc.date.accessioned2020-12-22T06:33:55Z-
dc.date.accessioned2020-12-22T06:33:55Z-
dc.date.available2020-12-22T06:33:55Z-
dc.date.available2020-12-22T06:33:55Z-
dc.date.created2020-04-20-
dc.date.issued2020-05-
dc.identifier.issn0163-7258-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/8631-
dc.description.abstract© 2020 The Authors. Genome engineering technologies right from viral vector-mediated to protein-based editing— which include zinc finger nucleases, TALENs, and CRISPR/Cas systems—have been improved significantly. These technologies have facilitated drug discovery and have resulted in the development of potential curative therapies for many intractable diseases. They can efficiently correct genetic errors; however, these technologies have limitations, such as off-target effects and possible safety issues, which need to be considered when employing these techniques in humans. Significant efforts have been made to overcome these limitations and to accelerate the clinical implementation of these technologies. In this review, we focus on the recent technological advancements in genome engineering and their applications in stem cells to enable efficient discovery of drugs and treatment of intractable diseases-
dc.description.uri1-
dc.language영어-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectDrug discovery-
dc.subjectGenome editing-
dc.subjectStem cells-
dc.subjectTherapeutic application-
dc.titleRecent advances in genome editing of stem cells for drug discovery and therapeutic application-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000528248800008-
dc.identifier.scopusid2-s2.0-85080937109-
dc.identifier.rimsid71661-
dc.contributor.affiliatedAuthorJaesuk Lee-
dc.contributor.affiliatedAuthorJin-Soo Kim-
dc.identifier.doi10.1016/j.pharmthera.2020.107501-
dc.identifier.bibliographicCitationPHARMACOLOGY & THERAPEUTICS, v.209, pp.107501-
dc.citation.titlePHARMACOLOGY & THERAPEUTICS-
dc.citation.volume209-
dc.citation.startPage107501-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusZINC-FINGER NUCLEASES-
dc.subject.keywordPlusHUMAN HEMATOPOIETIC STEM-
dc.subject.keywordPlusPROGENITOR CELLS-
dc.subject.keywordPlusPROGRAMMABLE NUCLEASES-
dc.subject.keywordPlusFANCONI-ANEMIA-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusRNA-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordAuthorGenome editing-
dc.subject.keywordAuthorStem cells-
dc.subject.keywordAuthorDrug discovery-
dc.subject.keywordAuthorTherapeutic application-
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > 1. Journal Papers (저널논문)
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