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Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm

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dc.contributor.authorYun Young Lee-
dc.contributor.authorHee Ho Park-
dc.contributor.authorWooram Park-
dc.contributor.authorHyelim Kim-
dc.contributor.authorJong Geol Jang-
dc.contributor.authorKyung Soo Hong-
dc.contributor.authorJae-Young Lee-
dc.contributor.authorHee Seung Seo-
dc.contributor.authorDong Hee Na-
dc.contributor.authorTae-Hyung Kim-
dc.contributor.authorYoung Bin Choy-
dc.contributor.authorJune Hong Ahn-
dc.contributor.authorWonhwa Lee-
dc.contributor.authorChun Gwon Park-
dc.date.accessioned2020-12-22T06:25:14Z-
dc.date.accessioned2020-12-22T06:25:14Z-
dc.date.available2020-12-22T06:25:14Z-
dc.date.available2020-12-22T06:25:14Z-
dc.date.created2020-11-16-
dc.date.issued2021-01-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/8425-
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of coronavirus not previously identified in humans. Globally, the number of confirmed cases and mortality rates of coronavirus disease 2019 (COVID-19) have risen dramatically. Currently, there are no FDA-approved antiviral drugs and there is an urgency to develop treatment strategies that can effectively suppress SARS-CoV-2-mediated cytokine storms, acute respiratory distress syndrome (ARDS), and sepsis. As symptoms progress in patients with SARS-CoV-2 sepsis, elevated amounts of cell-free DNA (cfDNA) are produced, which in turn induce multiple organ failure in these patients. Furthermore, plasma levels of DNase-1 are markedly reduced in SARS-CoV-2 sepsis patients. In this study, we generated recombinant DNase-1-coated polydopamine-poly(ethylene glycol) nanoparticulates (named long-acting DNase-1), and hypothesized that exogenous administration of long-acting DNase-1 may suppress SARS-CoV-2-mediated neutrophil activities and the cytokine storm. Our findings suggest that exogenously administered long-acting nanoparticulate DNase-1 can effectively reduce cfDNA levels and neutrophil activities and may be used as a potential therapeutic intervention for life-threatening SARS-CoV-2-mediated illnesses.-
dc.language영어-
dc.publisherPergamon Press Ltd.-
dc.titleLong-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000598391300004-
dc.identifier.scopusid2-s2.0-85094326875-
dc.identifier.rimsid73591-
dc.contributor.affiliatedAuthorChun Gwon Park-
dc.identifier.doi10.1016/j.biomaterials.2020.120389-
dc.identifier.bibliographicCitationBiomaterials, v.267-
dc.relation.isPartOfBiomaterials-
dc.citation.titleBiomaterials-
dc.citation.volume267-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.subject.keywordPlusEXTRACELLULAR TRAPS-
dc.subject.keywordPlusSEPSIS-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusDEATH-
dc.subject.keywordAuthorNETosis-
dc.subject.keywordAuthorCOVID-19-
dc.subject.keywordAuthorSepsis-
dc.subject.keywordAuthorDNase-
dc.subject.keywordAuthorNanoparticles-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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