BROWSE

Related Scientist

aim's photo.

aim
면역미생물공생연구단
more info

ITEM VIEW & DOWNLOAD

Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection

DC Field Value Language
dc.contributor.authorGoeun Lee-
dc.contributor.authorYun Jeong Na-
dc.contributor.authorBo-Gie Yang-
dc.contributor.authorJun-Pyo Choi-
dc.contributor.authorYong Bok Seo-
dc.contributor.authorChun-Pyo Hong-
dc.contributor.authorChangho Yun-
dc.contributor.authorDae Heon Kim-
dc.contributor.authorEun Ju Sohn-
dc.contributor.authorJeong Hee Kim-
dc.contributor.authorYoung Chul Sung-
dc.contributor.authorYoon-Keun Kim-
dc.contributor.authorMyoung Ho Jang-
dc.contributor.authorInhwan Hwang-
dc.date.available2015-04-20T05:12:09Z-
dc.date.created2015-01-30-
dc.date.issued2015-01-
dc.identifier.issn1467-7644-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/827-
dc.description.abstractPandemics in poultry caused by the highly pathogenic avian influenza (HPAI) A virus occur too frequently globally, and there is growing concern about the HPAI A virus due to the possibility of a pandemic among humans. Thus, it is important to develop a vaccine against HPAI suitable for both humans and animals. Various approaches are underway to develop such vaccines. In particular, an edible vaccine would be a convenient way to vaccinate poultry because of the behaviour of the animals. However, an edible vaccine is still not available. In this study, we developed a strategy of effective vaccination of mice by the oral administration of transgenic Arabidopsis plants (HA-TG) expressing haemagglutinin (HA) in the endoplasmic reticulum (ER). Expression of HA in the ER resulted in its high-level accumulation, N-glycosylation, protection from proteolytic degradation and long-term stability. Oral administration of HA-TG with saponin elicited high levels of HA-specific systemic IgG and mucosal IgA responses in mice, which resulted in protection against a lethal influenza virus infection with attenuated inflammatory symptoms. Based on these results, we propose that oral administration of freeze-dried leaf powders from transgenic plants expressing HA in the ER together with saponin is an attractive strategy for vaccination against influenza A virus.-
dc.description.uri1-
dc.language영어-
dc.publisherWILEY-BLACKWELL-
dc.subjecthighly pathogenic avian influenza virus, plant edible vaccine, ER-targeted haemagglutinin, adjuvant Saponin, mucosal immunity, influenza infection-
dc.titleOral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000346915000007-
dc.identifier.scopusid2-s2.0-84919876807-
dc.identifier.rimsid17188ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorGoeun Lee-
dc.contributor.affiliatedAuthorBo-Gie Yang-
dc.contributor.affiliatedAuthorChun-Pyo Hong-
dc.contributor.affiliatedAuthorChangho Yun-
dc.contributor.affiliatedAuthorMyoung Ho Jang-
dc.identifier.doi10.1111/pbi.12235-
dc.identifier.bibliographicCitationPLANT BIOTECHNOLOGY JOURNAL, v.2014, pp.1 - 11-
dc.citation.titlePLANT BIOTECHNOLOGY JOURNAL-
dc.citation.volume2014-
dc.citation.startPage1-
dc.citation.endPage11-
dc.date.scptcdate2018-10-01-
dc.description.wostc14-
dc.description.scptc14-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
첨부12. Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse