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An inducible system for in vitro and in vivo Fas activation using FKBP-FRB-rapamycin complex

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dc.contributor.authorSeokhwi Kim-
dc.contributor.authorJongpil Shin-
dc.contributor.authorHyunsik Oh-
dc.contributor.authorSangphil Ahn-
dc.contributor.authorNury Kim-
dc.contributor.authorWon Do Heo-
dc.date.available2020-10-14T08:14:18Z-
dc.date.created2020-01-07-
dc.date.issued2020-03-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7223-
dc.description.abstract© 2019 Elsevier Inc.The inducible activation system is valuable for investigating spatiotemporal roles of molecules. A chemically inducible activation system for Fas (CD95/APO-1), which works efficiently to induce apoptosis and leads non-apoptotic pathways, has not yet been developed. Here, we engineered a rapamycin-induced dimerization system of Fas consisting of FKBP and FRB proteins. Treatment of rapamycin specifically induces cellular apoptosis. In neurons and cells with high c-FLIP expression, rapamycin-induced Fas activation triggered the activation of the non-apoptotic pathway components instead of cell death. Intracranial delivery of the system could be utilized to induce apoptosis of tumor cells upon rapamycin treatment. Our results demonstrate a novel inducible Fas activation system which operates with high efficiency and temporal precision in vitro and in vivo promising a potential therapeutic strategy-
dc.description.uri1-
dc.language영어-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.titleAn inducible system for in vitro and in vivo Fas activation using FKBP-FRB-rapamycin complex-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000524737600030-
dc.identifier.scopusid2-s2.0-85076857268-
dc.identifier.rimsid71028-
dc.contributor.affiliatedAuthorNury Kim-
dc.contributor.affiliatedAuthorWon Do Heo-
dc.identifier.doi10.1016/j.bbrc.2019.12.072-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.523, no.2, pp.473 - 480-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume523-
dc.citation.number2-
dc.citation.startPage473-
dc.citation.endPage480-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusSPATIOTEMPORAL CONTROL-
dc.subject.keywordPlusFACTOR RECEPTOR-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusCASPASE-8-
dc.subject.keywordPlusABLATION-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusSIGNALS-
dc.subject.keywordPlusSINGLE-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusERK-
dc.subject.keywordAuthorFas-
dc.subject.keywordAuthorChemically inducible dimerization-
dc.subject.keywordAuthorRapamycin-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorNon-apoptotic pathway-
dc.subject.keywordAuthorGlioblastoma-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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