N-Heterocyclic carbene-catalyzed deaminative cross-coupling of aldehydes with Katritzky pyridinium salts
DC Field | Value | Language |
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dc.contributor.author | Inwon Kim | - |
dc.contributor.author | Honggu Im | - |
dc.contributor.author | Hyeonyeong Lee | - |
dc.contributor.author | Sungwoo Hong | - |
dc.date.available | 2020-07-06T06:43:32Z | - |
dc.date.created | 2020-04-20 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/7162 | - |
dc.description.abstract | This journal is © The Royal Society of Chemistry.By employing an N-heterocyclic carbene (NHC) catalyst, we developed a versatile catalytic system that enables deaminative cross-coupling reactions of aldehydes with redox-active pyridinium salts. Katritzky pyridinium salts behave as single-electron oxidants capable of generating alkyl radicals enabled by the redox properties of the enolate form of Breslow intermediates. The resultant alkyl radical undergoes efficient recombination with the NHC-bound aldehyde-derived carbonyl carbon radical for the formation of a C-C bond. The mild and transition metal-free reaction conditions tolerate a broad range of functional groups, and its utility has been further demonstrated by the modification of a series of peptide feedstocks and application to the three-component dicarbofunctionalization of olefins | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | N-Heterocyclic carbene-catalyzed deaminative cross-coupling of aldehydes with Katritzky pyridinium salts | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000528663000005 | - |
dc.identifier.scopusid | 2-s2.0-85082720513 | - |
dc.identifier.rimsid | 71864 | - |
dc.contributor.affiliatedAuthor | Inwon Kim | - |
dc.contributor.affiliatedAuthor | Honggu Im | - |
dc.contributor.affiliatedAuthor | Hyeonyeong Lee | - |
dc.contributor.affiliatedAuthor | Sungwoo Hong | - |
dc.identifier.doi | 10.1039/d0sc00225a | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.11, no.12, pp.3192 - 3197 | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3192 | - |
dc.citation.endPage | 3197 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | BETA-HYDROXYLATION | - |
dc.subject.keywordPlus | ACTIVE ALDEHYDES | - |
dc.subject.keywordPlus | REDOX BEHAVIOR | - |
dc.subject.keywordPlus | AMINES | - |
dc.subject.keywordPlus | ENALS | - |