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시냅스 뇌질환 연구단
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Distinct effects of reward and navigation history on hippocampal forward and reverse replays

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Title
Distinct effects of reward and navigation history on hippocampal forward and reverse replays
Author(s)
Baburam Bhattarai; Jong Won Lee; Min Whan Jung
Publication Date
2020-01
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.117, no.1, pp.689 - 697
Publisher
NATL ACAD SCIENCES
Abstract
© 2020 National Academy of Sciences. All rights reserved.To better understand the functional roles of hippocampal forward and reverse replays, we trained rats in a spatial sequence memory task and examined how these replays are modulated by reward and navigation history. We found that reward enhances both forward and reverse replays during the awake state, but in different ways. Reward enhances the rate of reverse replays, but it increases the fidelity of forward replays for recently traveled as well as other alternative trajectories heading toward a rewarding location. This suggests roles for forward and reverse replays in reinforcing representations for all potential rewarding trajectories. We also found more faithful reactivation of upcoming than already rewarded trajectories in forward replays. This suggests a role for forward replays in preferentially reinforcing representations for high-value trajectories. We propose that hippocampal forward and reverse replays might contribute to constructing a map of potential navigation trajectories and their associated values (a “value map”) via distinct mechanisms
URI
https://pr.ibs.re.kr/handle/8788114/7056
ISSN
0027-8424
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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