Synthesizing diffusion tensor imaging from functional MRI using fully convolutional networks

Abstract

Abstract Purpose Medical image synthesis can simulate a target modality of interest based on existing modalities and has the potential to save scanning time while contributing to efficient data collection. This study proposed a three-dimensional (3D) deep learning architecture based on a fully convolutional network (FCN) to synthesize diffusion-tensor imaging (DTI) from resting-state functional magnetic resonance imaging (fMRI).

Methods: fMRI signals derived from white matter (WM) exist and can be used for assessing WM alterations. We constructed an initial functional correlation tensor image using the correlation patterns of adjacent fMRI voxels as one input to the FCN. We considered T1-weighted images as an additional input to provide an algorithm with the structural information needed to synthesize DTI. Our architecture was trained and tested using a large-scale open database dataset (training n = 648; testing n = 293).

Results The average correlation value between synthesized and actual diffusion tensors for 38 WM regions was 0.808, which significantly improves upon an existing study (r = 0.480). We also validated our approach using two open databases. Our proposed method showed a higher correlation with the actual diffusion tensor than the conventional machine-learning method for many WM regions.

Conclusions Our method synthesized DTI images from fMRI images using a 3D FCN architecture. We hope to expand our method of synthesizing various other imaging modalities from a single image source. © 2019 Elsevier Ltd. All rights reserved.