BROWSE

Related Scientist

Researcher

정화진
시냅스 뇌질환 연구단
more info

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Cited 0 time in webofscience Cited 0 time in scopus
23 Viewed 5 Downloaded
Title
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Author(s)
Koopmans, F; Pim van Nierop; Maria Andres-Alonso; Andrea Byrnes; Tony Cijsouw; Marcelo P. Coba; L. Niels Cornelisse; Ryan J. Farrell; Hana L. Goldschmidt; Daniel P. Howrigan; Natasha K. Hussain; Cordelia Imig; Arthur P.H. de Jong; Hwajin Jung; Mahdokht Kohansalnodehi; Barbara Kramarz; Noa Lipstein; Ruth C. Lovering; Harold MacGillavry; Vittoria Mariano; Huaiyu Mi; Momchil Ninov; David Osumi-Sutherland; Rainer Pielot; Karl-Heinz Smalla; Haiming Tang; Katherine Tashman; Ruud F.G. Toonen; Chiara Verpelli; Rita Reig-Viader; Kyoko Watanabe; Jan van Weering; Tilmann Achsel; Ghazaleh Ashrafi; Nimra Asi; Tyler C. Brown; Pietro De Camilli; Marc Feuermann; Rebecca E. Foulger; Pascale Gaudet; Anoushka Joglekar; Alexandros Kanellopoulos; Robert Malenka; Roger A. Nicoll; Camila Pulido; Jaime de Juan-Sanz; Morgan Sheng; Thomas C. S€udhof; Hagen U. Tilgner; Claudia Bagni; A`lex Baye´ s; Thomas Biederer; Nils Brose; John Jia En Chua; Daniela C. Dieterich; Eckart D. Gundelfinger; Casper Hoogenraad; Richard L. Huganir; Reinhard Jahn; Pascal S. Kaeser; Eunjoon Kim; Michael R. Kreutz; Peter S. McPherson; Ben M. Neale; Vincent O’Connor; Danielle Posthuma; Timothy A. Ryan; Carlo Sala; Guoping Feng; Steven E. Hyman; Paul D. Thomas; August B. Smit; Matthijs Verhage
Publication Date
2019-07
Journal
NEURON, v.103, no.2, pp.217 - 234.e4
Publisher
CELL PRESS
Abstract
© 2019 Elsevier Inc.Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders (“synaptopathies”). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are exclusively based on published, expert-curated evidence. Using 2,922 annotations for 1,112 genes, we show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes. Many SynGO terms are significantly overrepresented among gene variations associated with intelligence, educational attainment, ADHD, autism, and bipolar disorder and among de novo variants associated with neurodevelopmental disorders, including schizophrenia. SynGO is a public, universal reference for synapse research and an online analysis platform for interpretation of large-scale -omics data (https://syngoportal.org and http://geneontology.org). The SynGO consortium presents a framework to annotate synaptic protein locations and functions and annotations for 1,112 synaptic genes based on published experimental evidence. SynGO reports exceptional features and disease associations for synaptic genes and provides an online data analysis platform
URI
https://pr.ibs.re.kr/handle/8788114/6304
ISSN
0896-6273
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
2019_158.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse