BROWSE

Related Scientist

rna's photo.

rna
rna연구단
more info

ITEM VIEW & DOWNLOAD

Interpretation of EBV infection in pan-cancer genome considering viral life cycle: LiEB (Life cycle of Epstein-Barr virus)

DC Field Value Language
dc.contributor.authorSong H.-
dc.contributor.authorLim Y.-
dc.contributor.authorIm H.-
dc.contributor.authorBae J.M.-
dc.contributor.authorKang G.H.-
dc.contributor.authorJunhak Ahn-
dc.contributor.authorDaehyun Baek-
dc.contributor.authorKim T.-Y.-
dc.contributor.authorYoon S.-S.-
dc.contributor.authorKoh Y.-
dc.date.available2019-08-19T02:06:43Z-
dc.date.created2019-03-19-
dc.date.issued2019-03-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/6002-
dc.description.abstractWe report a novel transcriptomic analysis workflow called LiEB (Life cycle of Epstein-Barr virus) to characterize distributions of oncogenic virus, Epstein-Barr virus (EBV) infection in human tumors. We analyzed 851 The Cancer Genome Atlas whole-transcriptome sequencing (WTS) data to investigate EBV infection by life cycle information using three-step LiEB workflow: 1) characterize virus infection generally; 2) align transcriptome sequences against a hybrid human-EBV genome, and 3) quantify EBV gene expression. Our results agreed with EBV infection status of public cell line data. Analysis in stomach adenocarcinoma identified EBV-positive cases involving PIK3CA mutations and/or CDKN2A silencing with biologically more determination, compared to previous reports. In this study, we found that a small number of colorectal adenocarcinoma cases involved with EBV lytic gene expression. Expression of EBV lytic genes was also observed in 3% of external colon cancer cohort upon WTS analysis. Gene set enrichment analysis showed elevated expression of genes related to E2F targeting and interferon-gamma responses in EBV-associated tumors. Finally, we suggest that interpretation of EBV life cycle is essential when analyzing its infection in tumors, and LiEB provides high capability of detecting EBV-positive tumors. Observation of EBV lytic gene expression in a subset of colon cancers warrants further research. © 2019, The Author(s)-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleInterpretation of EBV infection in pan-cancer genome considering viral life cycle: LiEB (Life cycle of Epstein-Barr virus)-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000460381600038-
dc.identifier.scopusid2-s2.0-85062587217-
dc.identifier.rimsid67533-
dc.contributor.affiliatedAuthorJunhak Ahn-
dc.contributor.affiliatedAuthorDaehyun Baek-
dc.identifier.doi10.1038/s41598-019-39706-0-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.9, no.1, pp.3465-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage3465-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
s41598-019-39706-0.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse